Results 181 to 190 of about 38,793 (285)

RNA-Targeting CRISPR–Cas Systems and Their Applications [PDF]

, 2020
Michał Burmistrz, Kamil Krakowski, Agata Krawczyk-Balska   +2 more
openalex   +1 more source

Advancements in CRISPR/Cas systems for disease treatment. [PDF]

Acta Pharm Sin B
Xu Y, Le H, Wu Q, Wang N, Gong C.
europepmc   +1 more source

PDIA3 Inhibition Facilitates Sensitivity of IKE‐Induced Ferroptosis via STAT3/LCN2 Axis to Improve Glioblastoma Therapy

Advanced Science, EarlyView.
In this manuscript, protein disulfide isomerase A3 (PDIA3) is identified as a key factor mediating the susceptibility of ferroptosis in GBM. Inhibition of PDIA3 enhances IKE or cystine starvation‐induced ferroptosis in GBM cells by resulting in the accumulation of lipid peroxidation and a reduction in GSH level.
Jie Zhang, Wei Wang, Xin Liu, Peifen Lu, Xinjing Liu, Qiucheng Nie, Siyuan Xin, Hong Li, Donglin Yu, Xinyue Zhang, Kailong Li, Xiaomin Han, Shuping Zhang, Wei Chong, Lili Sun, Wei Li, Tao Xin, Jin Jiao, Qiang Ma, Yiju Wei   +19 more
wiley   +1 more source

Characterization of CRISPR‐Cas systems in the Ralstonia solanacearum species complex [PDF]

, 2018
André da Silva Xavier, Juliana Cristina Fraleon de Almeida, Alessandra Gonçalves de Melo, Geneviève M. Rousseau, Denise M. Tremblay, Rafael Reis de Rezende, Sylvain Moineau, Poliane Alfenas‐Zerbini   +7 more
openalex   +1 more source

Acquisition of Spacers from Foreign Prokaryotic Genomes by CRISPR-Cas Systems in Natural Environments. [PDF]

Genome Biol Evol
Sures K, Esser SP, Bornemann TLV, Moore CJ, Soares AR, Plewka J, Figueroa-Gonzalez PA, Ruff SE, Moraru C, Probst AJ.   +9 more
europepmc   +1 more source

The Evolutionarily Conserved TPM1 Super‐Enhancer Drives Skeletal Muscle Regeneration via Mechanotransduction Signaling

Advanced Science, EarlyView.
By integrating biomechanical and epigenetic cues, the evolutionarily conserved TPM1 super‐enhancer drives myogenesis via TEAD4‐mediated chromatin looping. This mechanism produces species‐specific outputs (linear TPM1 mRNA in mice and CircTPM1 in bovine) that activate PI3K/AKT mechanotransduction and the MYH10/MYL3 axis to execute cytoskeletal ...
Ruimen Zhang, Wanyou Feng, Yanyan Yang, Yu Pan, Chaoxia Zou, Leyi Wang, Sanbao Zhang, Yimin Zhao, Yongmei Wu, Jinling Wang, Jianwei Zou, Kehe Cen, Yongwang Zhang, Han Huang, Yurong Xu, Li Zhong, Hailong Gong, Juanru Cheng, Jingyuan Liang, Zihua Zheng, Qinyang Jiang, Jingwei Wei, Hui Li, Minhui Liang, Deshun Shi, Sufang Yang, Yanfei Deng, Yingming Wei   +27 more
wiley   +1 more source

Additional file 6 of Exploring the success of Brazilian endemic clone Pseudomonas aeruginosa ST277 and its association with the CRISPR-Cas system type I-C

, 2020
Melise Chaves Silveira, Cláudio Marcos Rocha-de-Souza, Rodolpho Mattos Albano, Ivson Cassiano de Oliveira Santos, Ana Paula D’Alincourt Carvalho-Assef   +4 more
openalex   +1 more source

Comparative analysis of CRISPR-Cas systems of <em>Yersinia pestis</em> and <em>Escherichia coli</em> strains [PDF]

, 2017
Uchenna N. Eze, Ifekthar Bin Naser, Olunuga Omotola, Ubenyi Stanley Mary, Ugwu Chukwuebuka   +4 more
openalex   +1 more source

Discarded diversity: novel megaphages, auxiliary metabolic genes, and virally encoded CRISPR-Cas systems in landfills. [PDF]

Virol J
George NA, Zhou Z, Anantharaman K, Hug LA.   +3 more
europepmc   +1 more source

Mutual Exclusion Analysis Shows that DUSP9 Negatively Regulates PD‐L1 Expression and Acts as a Target to Enhance Anti‐PD‐1 Efficacy

Advanced Science, EarlyView.
A mutually exclusive screening system is established to identify negative regulators of highly plastic genes. Dual specificity phosphatase (DUSP9) is a novel negative regulatory molecule of PD‐L1 by dephosphorylating STAT3, and acts as a target molecule in combination with PD‐1 antibody for tumor immunotherapy and a new clinical biomarker for ...
Yuzhe Hu, Ling Tang, Zheng Kuang, Danyi Huang, Ting Li, Gaofei Yin, Yingyu Chen, Wei Guo, Wenling Han, Pingzhang Wang   +9 more
wiley   +1 more source