Results 191 to 200 of about 713,183 (311)

CdpR Inhibits CRISPR-Cas Adaptive Immunity to Lower Anti-viral Defense while Avoiding Self-Reactivity

iScience, 2019
Summary: CRISPR-Cas systems as adaptive immunity in bacteria and archaea battle against bacteriophages. However, little is known how CRISPR-Cas systems are precisely regulated to effectively eliminate intruders while not inducing self-reactivity.
Ping Lin, Qinqin Pu, Guanwang Shen, Rongpeng Li, Kai Guo, Chuanmin Zhou, Haihua Liang, Jianxin Jiang, Min Wu   +8 more
doaj  

Chromosomal targeting by CRISPR-Cas systems can contribute to genome plasticity in bacteria [PDF]

, 2013
Ron L. Dy, Andrew R. Pitman, Peter C. Fineran   +2 more
openalex   +1 more source

Engineering the Immune Response to Biomaterials

Advanced Science, EarlyView.
This paper reviews immune responses to biomaterials, stages of evolution in relation to managing these responses ranging from preventing to modulating them. It also discusses state‐of‐the‐art strategies to modulate these responses and modes of their delivery.
Abolfazl Salehi Moghaddam, Mehran Bahrami, Einollah Sarikhani, Rumeysa Tutar, Yavuz Nuri Ertas, Faleh Tamimi, Ali Hedayatnia, Clotilde Jugie, Houman Savoji, Asma Talib Qureshi, Muhammad Rizwan, Chima V. Maduka, Nureddin Ashammakhi   +12 more
wiley   +1 more source

Cluster integrable systems [PDF]

arXiv
In these lecture notes, we give an introduction to cluster integrable systems. The topics include relativistic Toda systems, moduli spaces of framed local systems, Goncharov-Kenyon integrable systems, and quantization.
arxiv  

Deep Learning‐Enhanced Hand‐Driven Microfluidic Chip for Multiplexed Nucleic Acid Detection Based on RPA/CRISPR

Advanced Science, EarlyView.
Efficient R‐CHIP HR‐HPV Screening System: The R‐CHIP system utilizes the RPA/CRISPR method, a hand‐driven centrifugal microfluidic device, a smartphone micro‐imaging system, and the ResNet‐18 deep‐learning algorithm to simplify the sample detection process, ensure accurate results, and reduce costs.
Tao Xu, Ying Zhang, Shunji Li, Chenxi Dai, Hongguo Wei, Dongjuan Chen, Yunjun Zhao, He Liu, Deliang Li, Peng Chen, Bi‐Feng Liu, Ye Tian   +11 more
wiley   +1 more source

Semaphorin 3E–Plexin D1 Axis Drives Lung Fibrosis through ErbB2‐Mediated Fibroblast Activation

Advanced Science, EarlyView.
TGF‐β1 stimulation in fibroblasts leads to increased Furin expression, Furin‐mediated cleavage of P87‐Sema3E to P61‐Sema3E, which affects fibroblast function through the autocrine pathway, and the P61‐Sema3E‐PlexinD1 axis promotes fibroblast activation, proliferation and migration by affecting ErbB2 phosphorylation, which in turn activates the ErbB2 ...
Zhesong Deng, Jinkun Chen, Ruonan Yang, Yuan Zhan, Shanshan Chen, Jiaheng Zhang, Hao Fu, Yiya Gu, Qian Huang, Jixing Wu, Lianyu Shan, Abdelilah Soussi Gounni, Jungang Xie   +12 more
wiley   +1 more source

The CRISPR/Cas Immune System Is an Operon Regulated by LeuO, H-NS, and Leucine-Responsive Regulatory Protein in Salmonella enterica Serovar Typhi

, 2011
Liliana Medina-Aparicio, Javier E. Rebollar-Flores, Ana L. Gallego-Hernández, Alma Luísa Revilla Vázquez, L. Olvera, Rosa-María Gutiérrez-Rios, Edmundo Calva, Ismael Hernández-Lucas   +7 more
openalex   +1 more source

MeCP2 Lactylation Protects against Ischemic Brain Injury by Transcriptionally Regulating Neuronal Apoptosis

Advanced Science, EarlyView.
MeCP2 lactylation protects against ischemic stroke by reducing brain infarct volume and improving neurological outcomes. Lactylation at K210/K249 exerts neuroprotective effects by repressing the transcription of apoptosis‐associated genes, including Pdcd4 and Pla2g6. HDAC3 and p300 serve as key regulatory enzymes for MeCP2 lactylation following stroke.
Min Sun, Yuxin Zhang, Rui Mao, Yan Chen, Pinyi Liu, Lei Ye, Siyi Xu, Junqiu Jia, Shu Shu, Huiya Li, Yanping Yin, Shengnan Xia, Yanting Chen, Yun Xu   +13 more
wiley   +1 more source

Demonstrating the Use of a Fungal Synthesized Quinone in a Redox Flow Battery

Batteries &Supercaps, Volume 6, Issue 1, January 2023., 2023
Biobased: The filamentous fungus can be used as an environmentally and sustainable benign source to produce the bio‐based quinone phoenicin. This natural compound shows electrochemical properties, which can be used as the active material in the negative electrolyte in a redox flow battery with results showing that biologically produced quinones may ...
Charlotte Overgaard Wilhelmsen, Sebastian Birkedal Kristensen, Oliver Nolte, Ivan A. Volodin, Johan Vormsborg Christiansen, Thomas Isbrandt, Trine Sørensen, Celine Petersen, Teis Esben Sondergaard, Kåre Lehmann Nielsen, Thomas Ostenfeld Larsen, Jens Christian Frisvad, Martin D. Hager, Ulrich S. Schubert, Jens Muff, Jens Laurids Sørensen   +15 more
wiley   +1 more source

Characterization of CRISPR-Cas Systems in Shewanella algae and Shewanella haliotis: Insights into the Adaptation and Survival of Marine Pathogens

Pathogens
CRISPR-Cas systems are adaptive immune mechanisms present in most prokaryotes that play an important role in the adaptation of bacteria and archaea to new environments.
Jui-Hsing Wang, Po-Tsang Huang, Yao-Ting Huang, Yan-Chiao Mao, Chung-Hsu Lai, Ting-Kuang Yeh, Chien-Hao Tseng, Chih-Chuan Kao   +7 more
doaj   +1 more source