Results 191 to 200 of about 58,663 (324)
Recent Advances in mRNA Delivery Systems for Cancer Therapy
Advanced Science, EarlyView.This review systematically investigates the applications of mRNA therapy in cancer treatment, with particular emphasis on nonviral delivery systems, targeting strategies, stimulus‐responsive systems, and local delivery methods. Concluding with a meticulous evaluation, the review sheds light on the prevailing challenges while illuminating promising ...
Zheng Zhang +9 more
wiley +1 more source
New CRISPR–Cas systems from uncultivated microbes [PDF]
, 2016 David Burstein +7 more
openalex +1 more source
Advanced Science, EarlyView.This study identifies MTCH2 as a crucial regulator of ferroptosis in colorectal cancer (CRC) progression. High expression of MTCH2 is correlated with poor prognosis in CRC patients. Furthermore, MTCH2 depletion induces ferroptosis to suppress CRC liver metastasis via the E2F4/TFRC axis and sensitizes tumors to sorafenib treatment, supporting MTCH2 as a
Pu Xing +18 more
wiley +1 more source
Friendly Fire: Biological Functions and Consequences of Chromosomal Targeting by CRISPR-Cas Systems [PDF]
, 2016 Gary E. Heussler, George A. O’Toole
openalex +1 more source
Advanced Science, EarlyView.Nanopriming enhances plant resilience to environmental challenges; however, its effectiveness across diverse genetic backgrounds, including genetic modifications and natural variations, remains uncertain. These findings demonstrate that nanopriming improves efficacy when natural genetic variations are considered, particularly in genetically modified ...
Yining Wu +4 more
wiley +1 more source
A Phase‐Separated SR Protein Reprograms Host Pre‐mRNA Splicing to Enhance Disease Susceptibility
Advanced Science, EarlyView.This study identifies SR30, a splicing factor, as a negative regulator of tomato immunity. During Phytophthora infestans infection, the elevated SR30 forms nuclear condensates to suppress the alternative splicing (AS) of defense‐related genes in a phase separation manner.
Dong Yan +11 more
wiley +1 more source
HeliyonThis study employed a comprehensive genome-mining approach to characterize CRISPR-Cas systems in Lactobacillus delbrueckii strains. The analysis involved retrieving 105 genome sequences to explore the variety, occurrence, and evolution of CRISPR-Cas ...
Bahman Panahi +3 more
doaj
Type III CRISPR-Cas System: Introduction And Its Application for Genetic Manipulations [PDF]
, 2016 Tao Liu +4 more
openalex +1 more source
Evolution of CRISPR/Cas Systems for Precise Genome Editing. [PDF]
Int J Mol Sci, 2023 Hryhorowicz M, Lipiński D, Zeyland J.
europepmc +1 more source