Results 211 to 220 of about 10,050,452 (244)

Pathological Signal‐Responsive Nanoplatforms for Sepsis: Integrating Biomarker Sensing With Spatiotemporal Drug Delivery and Immunomodulation

Advanced Science, EarlyView.
Biomarker‐triggered nanoplatforms transform sepsis therapy by coupling pathological sensing with precision drug release. This review reveals how microenvironment‐responsive nanomedicines enable stage‐specific intervention, improve therapeutic efficacy, and minimize systemic toxicity, while highlighting emerging opportunities for AI‐assisted and ...
Yukun Liu, Kang Wang, Kwet Kyawl Yan, Zhikai Xu, Xuan Zhao, Xiangjun Bai, Zhanfei Li, Yuchang Wang   +7 more
wiley   +1 more source

Nanotechnology-leveraged CRISPR/Cas systems: icebreaking in trace cancer-related nucleic acids biosensing. [PDF]

Mol Cancer
Peng W, Shi M, Hu B, Jia J, Li X, Wang N, Man S, Ye S, Ma L.   +8 more
europepmc   +1 more source

Molecular Bases and Genetic Design of Rice Disease Resistance for Optimized Yield and Sustainable Agriculture

Advanced Science, EarlyView.
This study integrates rice immune perception, signal transduction, and resistance output into a multi‐omics framework. By combining high‐throughput sequencing, phenomics, and AI‐assisted design with marker‐assisted selection, gene editing, and rapid domestication, we aim to accelerate the precise breeding of disease‐resistant rice varieties by ...
Xinyue Hou, Yuanjiang Cui, Chaoqing Ding, Qian Qian, Deyong Ren   +4 more
wiley   +1 more source

Design of a Novel Diamine Biosensor to Guide the Engineering of Escherichia coli for Cadaverine Overproduction

Advanced Science, EarlyView.
A high‐throughput screening platform was established by integrating an in vivo cadaverine biosensor with a fluorescence‐activated cell sorting (FACS) system. Biosensor‐driven specific exporter tuning, pathway optimization and genome‐wide target mining were conducted to maximize cadaverine production in Escherichia coli.
Jia Feng, Getao Liu, Ding Ma, Jiaxiang Yuan, Xinyi Zhang, Weihao Wang, Chen Ma, Yang Liao, Siyuan Gao, Lei Qin, Jiao Feng, Sheng Xu, Xin Wang, Kequan Chen   +13 more
wiley   +1 more source

Important applications of DNA nanotechnology combined with CRISPR/Cas systems in biotechnology. [PDF]

RSC Adv
Huang Y, Chen Z, Huang H, Ding S, Zhang M.   +4 more
europepmc   +1 more source

RBM25 Drives Hepatocellular Carcinoma Progression by Stabilizing YAP Through Regulating Oncogenic Splicing‐switch of MYPT1

Advanced Science, EarlyView.
This study establishes that the RBM25‐PRPF40A interaction modulates MYPT1 splicing, promoting the production of the oncogenic long isoform. This isoform stabilizes YAP by suppressing its phosphorylation and subsequent proteasomal degradation, ultimately accelerating tumor growth.
Wenjing Zhang, Lili Zhi, Tian Huang, Lingya Feng, Chaoqun Chen, Huanhuan Wei, Xiaolong Liu, Lei Chen, Jinrui Zhang, Ge Zhang, Baofeng Zhao, Rong Liu, Dan Chen, Yangfan Qi, Yang Wang   +14 more
wiley   +1 more source

Comparative Analysis of Spacer Targets in CRISPR-Cas Systems of Starter Cultures. [PDF]

Acta Naturae
Fatkulin AA, Chuksina TA, Sorokina NP, Smykov IT, Kuraeva EV, Masezhnaya ES, Smagina KA, Shkurnikov MY.   +7 more
europepmc   +1 more source

Relationship Between CRISPR-Cas Systems and Acquisition of Tetracycline Resistance in Non-Clinical Enterococcus Populations in Bulgaria. [PDF]

Antibiotics (Basel)
Pandova M, Kizheva Y, Hristova P.
europepmc   +1 more source

Orthogonal transcriptional modulation and gene editing using multiple CRISPR-Cas systems. [PDF]

Mol Ther
Broksø AD, Bendixen L, Fammé S, Mikkelsen K, Jensen TI, Bak RO.   +5 more
europepmc   +1 more source

Role of CRISPR-Cas systems in periodontal disease pathogenesis and potential for periodontal therapy: A review. [PDF]

Mol Oral Microbiol
Chopra A, Bhuvanagiri G, Natu K, Chopra A.   +3 more
europepmc   +1 more source