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Role of CRISPR-Cas systems and anti-CRISPR proteins in bacterial antibiotic resistance. [PDF]
HeliyonKadkhoda H +8 more
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Correction to 'DNA target binding-induced pre-crRNA processing in type II and V CRISPR-Cas systems'. [PDF]
Nucleic Acids Reseuropepmc +1 more source
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RNA-targeting CRISPR–Cas systems
Nature Reviews Microbiology, 2022CRISPR-Cas is a widespread adaptive immune system in bacteria and archaea that protects against viral infection by targeting specific invading nucleic acid sequences. Whereas some CRISPR-Cas systems sense and cleave viral DNA, type III and type VI CRISPR-Cas systems sense RNA that results from viral transcription and perhaps invasion by RNA viruses ...
Stan J J Brouns +2 more
exaly +3 more sources
Evolution and classification of the CRISPR–Cas systems [PDF]
Nature Reviews Microbiology, 2011 The CRISPR-Cas (clustered regularly interspaced short palindromic repeats-CRISPR-associated proteins) modules are adaptive immunity systems that are present in many archaea and bacteria. These defence systems are encoded by operons that have an extraordinarily diverse architecture and a high rate of evolution for both the cas genes and the unique ...
John Van Der Oost +2 more
exaly +4 more sources
An updated evolutionary classification of CRISPR–Cas systems [PDF]
Nature Reviews Microbiology, 2015 The evolution of CRISPR-cas loci, which encode adaptive immune systems in archaea and bacteria, involves rapid changes, in particular numerous rearrangements of the locus architecture and horizontal transfer of complete loci or individual modules. These dynamics complicate straightforward phylogenetic classification, but here we present an approach ...
John Van Der Oost +2 more
exaly +4 more sources
The CRISPR/Cas System in Human Cancer
2023The use of CRISPR as a genetic editing tool modified the oncology field from its basic to applied research for opening a simple, fast, and cheaper way to manipulate the genome. This chapter reviews some of the major uses of this technique for in vitro- and in vivo-based biological screenings, for cellular and animal model generation, and new derivative
Martín Hérnan, Bonamino +1 more
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Enhancing CRISPR/Cas systems with nanotechnology
Trends in Biotechnology, 2023CRISPR/Cas systems have revolutionized biology and medicine, and have led to new paradigms in disease diagnostics and therapeutics. However, these complexes suffer from key limitations regarding barriers to cellular entry, stability in biological environments, and off-target effects.
Rupali Chowdhry +5 more
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Application of CRISPR-Cas systems in neuroscience
2021CRISPR-Cas systems have, over the years, emerged as indispensable tools for Genetic interrogation in contexts of clinical interventions, elucidation of genetic pathways and metabolic engineering and have pervaded almost every aspect of modern biology.
Deepro, Bonnerjee, Sangram, Bagh
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