Results 211 to 220 of about 38,793 (285)

CRISPR-Cas as a Chemically Programmable System: Advances in Modulation and Delivery [PDF]

Yukti Sabikhi, Anshika Singh, Chhavi Dudeja, Sameen Masroor, Richa Gupta   +4 more
openalex   +1 more source

Disparate mechanisms counteract extraneous CRISPR RNA production in type II-C CRISPR-Cas systems. [PDF]

Microlife
Feussner M, Migur A, Mitrofanov A, Alkhnbashi OS, Backofen R, Beisel CL, Weinberg Z.   +6 more
europepmc   +1 more source

Connexin43 Deficiency Leads to Ventricular Arrhythmias by Reprogramming Proline Metabolism

Advanced Science, EarlyView.
The study demonstrated that connexin43 (Cx43) knockout caused arrhythmic phenotype and decreased proline content in vitro and in vivo. Mechanistically, Cx43 interacts with the amino acid transporter SNAT2 (sodium‐dependent neutral amino acid transporter), and its deficiency disrupts proline transport and metabolism.
Hangying Ying, Hangping Fan, Yunhe Wang, Ruhong Jiang, Dongsheng Cai, Hui Cheng, Hao Wang, Chenyang Jiang, Ping Liang   +8 more
wiley   +1 more source

Cyanobacterial type I CRISPR-Cas systems: distribution, mechanisms, and genome editing applications. [PDF]

Front Bioeng Biotechnol
Zhang Y, Yang S, Zheng X, Tan X.
europepmc   +1 more source

Natural Negative Feedback Loops Confer Indica‐Japonica Differentiation for Grain Size Homeostasis in Rice

Advanced Science, EarlyView.
This study reveals the genetic and molecular mechanisms controlling grain size homeostasis through fine‐tuning OsGRX8 self‐expression by two natural negative feedback loops functioning in redox‐dependent or ‐independent manners and identifies two self‐regulatory haplotypes (SRHs) for the subspecies differentiation in rice.
Xingxing Li, Meng‐en Wu, Ziqi Qiao, Junkui Huang, Juncheng Zhang, Yang Ding, Junqing Zhu, Jingyue Xu, Yuxin Huang, Wei Li, Xiaomin Su, Yue Ding, Jianwei Zhang, Yibo Li   +13 more
wiley   +1 more source

Pirin Transcriptionally Regulates PLA2G4A To Inhibit Ferroptosis in Colorectal Cancer via Lipid Profile Remodeling

Advanced Science, EarlyView.
This study identifies Pirin (PIR), an iron‐binding protein, as a critical ferroptosis suppressor in colorectal cancer through lipid membrane remodeling. PIR, induced by NRF2 during ferroptotic stress, transcriptionally regulates PLA2G4A to shift cellular lipid composition away from ferroptosis‐permissive polyunsaturated phospholipids.
Wei Shi, Yue Qi Ong, Prativa Majee, Esther SM Wong, Amhed Missael Vargas Velazquez, Kerem Fidan, Pierce Kah‐Hoe Chow, Wai Leong Tam, Ker Kan Tan, Iain Beehuat Tan, Vinay Tergaonkar   +10 more
wiley   +1 more source

Is the Patent System the Way Forward with the CRISPR-Cas 9 Technology?

, 2020
Franc Mali
openalex   +2 more sources

Cytosolic CRISPR RNAs for efficient application of RNA-targeting CRISPR-Cas systems. [PDF]

EMBO Rep
Cheng ECK, Lam JKC, Kwon SC.
europepmc   +1 more source

Genome‐Wide Codon Reprogramming Enables a Multifactorially Attenuated Influenza Vaccine with Broad Cross‐Protection

Advanced Science, EarlyView.
Genome‐wide codon reprogramming of influenza A virus introduces 1956 synonymous mutations across five segments and elevates CpG content, causing defective NA packaging, loss of NS1 accumulation, and enhanced ZAP‐mediated antiviral responses without affecting RNA or protein synthesis. These mechanisms result in profound attenuation and potent homologous
Yang Wang, Tianxin Ma, Yujiao He, Qinming Li, Kailin Mai, Minying Mo, Chenyang Cao, Jiahui Li, Pei Feng, Jiaojiao Peng, Jing Sun, Weiqi Pan, Zifeng Yang, Ling Chen   +13 more
wiley   +1 more source

Combating Antimicrobial Resistance: Innovative Strategies Using Peptides, Nanotechnology, Phages, <i>Quorum Sensing</i> Interference, and CRISPR-Cas Systems. [PDF]

Pharmaceuticals (Basel)
Jacobowski AC, Boleti APA, Cruz MV, Santos KFDP, de Andrade LRM, Frihling BEF, Migliolo L, Paiva PMG, Teodoro PE, Teodoro LPR, Macedo MLR.   +10 more
europepmc   +1 more source