Results 261 to 270 of about 58,663 (324)

CRISPR-Cas Systems in the Fight Against Antimicrobial Resistance: Current Status, Potentials, and Future Directions. [PDF]

Infect Drug Resist
Ahmed MM, Kayode HH, Okesanya OJ, Ukoaka BM, Eshun G, Mourid MR, Adigun OA, Ogaya JB, Mohamed ZO, Lucero-Prisno DE.   +9 more
europepmc   +1 more source

Akkermansia Muciniphila Alleviates Severe Acute Pancreatitis via Amuc1409‐Ube2k‐Foxp3 Axis in Regulatory T Cells

Advanced Science, EarlyView.
Akkermansia depletion correlates with acute pancreatitis (AP) severity. A. muciniphila and its protein Amuc_1409 mitigate pancreatic/systemic inflammation by expanding Tregs and IL‐10. Mechanistically, Amuc_1409 binds Ube2k, inhibiting Foxp3 ubiquitination to stabilize Treg differentiation and IL‐10 production, countering SAP‐induced SIRS/CARS ...
Jinyan Xie, Lijun Du, Yunkun Lu, Xiuliu Guo, Xinyuan Zhou, Yifan Tong, Bo Shen, Xin Yu, Feng Guo, Hong Yu   +9 more
wiley   +1 more source

Competition between mobile genetic elements drives optimization of a phage-encoded CRISPR-Cas system: Insights from a natural arms-race [PDF]

, 2018
Amelia C. McKitterick, Kristen N. LeGault, Angus Angermeyer, Muniral Alam, Kimberley D. Seed   +4 more
openalex   +1 more source

Role of CRISPR-Cas systems in periodontal disease pathogenesis and potential for periodontal therapy: A review. [PDF]

Mol Oral Microbiol
Chopra A, Bhuvanagiri G, Natu K, Chopra A.   +3 more
europepmc   +1 more source

Microbial Biosensor for Sensing and Treatment of Intestinal Inflammation

Advanced Science, EarlyView.
The engineered calprotectin biosensor detects gut inflammation, processes the signal through genetic regulation, and responds by expressing the reporter sfGFP and the therapeutic protein secIL10. This dual functionality enables the engineered biosensor not only to sense but also to mitigate gut inflammation, highlighting its potential for disease ...
Duolong Zhu, Jeffrey Galley, Jason Pizzini, Elena Musteata, Martin V. Douglas, Walter J. Chazin, Eric P. Skaar, Jeffrey J. Tabor, Robert A. Britton   +8 more
wiley   +1 more source

The search and analysis of a CRISPR-Cas system in Escherichia coli HS with subsequent scanning for the corresponding phage races based on the spacers of the detected CRIPSR array using bioinformatic methods [PDF]

, 2018
Е. И. Иванова, Yu. P. Dzhioev, A.Yu. Borisenko, N. P. Peretolchina, Л. А. Степаненко, Е. В. Григорова, A.I. Paramonov, У. М. Немченко, T. V. Tunik, Е. А. Кунгурцева   +9 more
openalex   +1 more source

Harnessing CRISPR/Cas Systems for DNA and RNA Detection: Principles, Techniques, and Challenges. [PDF]

Biosensors (Basel)
Son H.
europepmc   +1 more source

Exosomal CMTM4 Induces Immunosuppressive Macrophages to Promote Ovarian Cancer Progression and Attenuate Anti‐PD‐1 Immunotherapy

Advanced Science, EarlyView.
In ovarian tumors with high CMTM4 expression, exosomes transfer CMTM4 to macrophages, upregulating ICAM1 and promoting M2 polarization via p65 nuclear translocation. This suppresses immunity by increasing PD‐1 and Tregs while reducing CD8+ T cells.
Bo Yin, Jianyi Ding, Jie Liu, Haoran Hu, Yashi Zhu, Meiqin Yang, Huijuan Zhou, Baoyou Huang, Tiefeng Huang, Mengjie Li, Yinyan He, Ang Li, Lingfei Han   +12 more
wiley   +1 more source

DNA target binding-induced pre-crRNA processing in type II and V CRISPR-Cas systems. [PDF]

Nucleic Acids Res
Chen J, Lin X, Xiang W, Chen Y, Zhao Y, Huang L, Liu L.   +6 more
europepmc   +1 more source

An Amygdala‐hippocampus Circuit for Endocannabinoid Modulation of Anxiety Avoidance

Advanced Science, EarlyView.
This study employs three synapse‐specific endocannabinoids (eCB) probes to monitor dynamic eCB release, activate CB1Rs and knockdown 2‐AG biosynthesis enzymes in glutamatergic anterior basolateral amygdala ‐ ventral hippocampus (aBLA–vHPC) circuit. At aBLA–vHPC circuits, activation of CB1Rs reduce anxiety avoidance, and knockdown of eCB biosynthesis ...
Bao Xue, Mao‐Xing Zhang, Xiao‐Chen Bi, Shou‐Peng Lai, Xin‐Tian Bie, Yuan Dong, Jian‐Feng Li, Fang Gao, Xia Zhang, Ying Wang   +9 more
wiley   +1 more source