Results 281 to 290 of about 713,183 (311)
Pan‐cancer analysis shapes the understanding of cancer biology and medicine
Cancer Communications, EarlyView.Abstract Advances in multi‐omics datasets and analytical methods have revolutionized cancer research, offering a comprehensive, pan‐cancer perspective. Pan‐cancer studies identify shared mechanisms and unique traits across different cancer types, which are reshaping diagnostic and treatment strategies.
Xiaoping Cen +21 more
wiley +1 more source
Cancer Communications, EarlyView.Abstract Background Hepatocellular carcinoma (HCC) is a deadly malignancy known for its ability to evade immune surveillance. NOP2/Sun RNA methyltransferase family member 2 (NSUN2), an RNA methyltransferase involved in carcinogenesis, has been associated with immune evasion and energy metabolism reprogramming.
Jinhua Jiang +6 more
wiley +1 more source
A semi-lethal CRISPR-Cas system permits DNA acquisition in Enterococcus faecalis
, 2017 Karthik Hullahalli +3 more
openalex +1 more source
Combating cancer immunotherapy resistance: a nano‐medicine perspective
Cancer Communications, EarlyView.Abstract Cancer immunotherapy offers renewed hope for treating this disease. However, cancer cells possess inherent mechanisms that enable them to circumvent each stage of the immune cycle, thereby evading anti‐cancer immunity and leading to resistance.
Xiangyi Kong +10 more
wiley +1 more source
Cytoskeleton, EarlyView.ABSTRACT Sarcomeres are the fundamental contractile units of striated muscle. The functional roles of the cardiac‐specific myosin heavy chains, MYH6 (α myosin II) and MYH7 (β myosin II) during sarcomere assembly remain controversial. To address this, we utilized a selective MYH7 inhibitor, mavacamten, in combination with siRNA‐mediated knockdown of ...
James B. Hayes, Dylan T. Burnette
wiley +1 more source
The PP2A‐B56 Binding Site LxxIxE Contributes to Asp‐Mediated Spindle Pole Stability
Cytoskeleton, EarlyView.ABSTRACT The organization of microtubules into a mitotic spindle is critical for animal cell proliferation and involves the cooperation of hundreds of proteins whose molecular roles and regulation are not fully understood. The protein product of the Drosophila gene abnormal spindle, Asp, is a microtubule‐associated protein required for correct mitotic ...
Margaux Quiniou +6 more
wiley +1 more source
Harnessing Viral Proteases for Cellular and Molecular Engineering
Chemistry–Methods, EarlyView.Engineered viral proteases (VIPs) provide programmable control of protein function with high specificity and low toxicity. Integrated with chemogenetic and optogenetic modules, these VIP systems enable logic gate manipulation for targeted regulation of cell signaling, gene expression, protein secretion, and degradation, thereby offering versatile ...
Mingguang Cui +2 more
wiley +1 more source
Drug Testing and Analysis, EarlyView.Scenarios of drug exposure and administration as well as detection assays for drugs and methods of sports doping published between 2023 and 2024 are critically reviewed and evaluated in context with the Prohibited List 2024 as established by the World Anti‐Doping Agency.
Mario Thevis +2 more
wiley +1 more source
Developmental Dynamics, EarlyView.Abstract Background Environmental influence is critical for embryogenesis but is significantly under‐appreciated under lab conditions, which are not typically designed to robustly test environmental variability. Here, we report environmental effects on the developmental phenotype of zebrafish lacking the transcription factor Grainyhead‐like 3 (grhl3 ...
Nishanthi Mathiyalagan +5 more
wiley +1 more source