Results 91 to 100 of about 333,361 (210)

Data-Driven Prediction of CRISPR-Based Transcription Regulation for Programmable Control of Metabolic Flux [PDF]

arXiv, 2017
Multiplex and multi-directional control of metabolic pathways is crucial for metabolic engineering to improve product yield of fuels, chemicals, and pharmaceuticals. To achieve this goal, artificial transcriptional regulators such as CRISPR-based transcription regulators have been developed to specifically activate or repress genes of interest.
arxiv  

A CRISPR tool for Yersinia analysis? [PDF]

, 2005
Sheilagh Molloy
openalex   +1 more source

A Guild of 45 CRISPR-Associated (Cas) Protein Families and Multiple CRISPR/Cas Subtypes Exist in Prokaryotic Genomes

, 2005
Daniel H. Haft, Jeremy Selengut, Emmanuel F. Mongodin, William Nelson   +3 more
openalex   +3 more sources

Small CRISPR RNAs Guide Antiviral Defense in Prokaryotes [PDF]

, 2008
Stan J. J. Brouns, Matthijs M. Jore, Magnus Lundgren, Edze R. Westra, Rik J. H. Slijkhuis, Ambrosius P. Snijders, Mark J. Dickman, Kira S. Makarova, Eugene V. Koonin, John van der Oost   +9 more
openalex   +1 more source

274 Development of CTX112 a next generation allogeneic multiplexed CRISPR-edited CART cell therapy with disruptions of the TGFBR2 and Regnase-1 genes for improved manufacturing and potency

Journal for ImmunoTherapy of Cancer, 2023
Sarah Cohen, Jacob Waldman, Andrew Dunn, Thao Nguyen, Jonathan Terrett, Brigid Mcewan, Meghna Kuppuraju, Mohammed Ghonime, Robert Chain, Zinkal Padalia, Demetrios Kalaitzidis, Elizabeth Koch, Lauren Zakas, Nivedita Jaishankar, Davis Settipane, Paul Tetteh, Mary-Lee Dequeant, Sushant Karnik, Chandirasegaran Massilamany, Henia Dar, Melanie Allen, Laura Serwer, Melanie Butler-Gauthier, Parin Sripakdeevong, Shashwat Nagar, Yin Tang, Nicole Flanagan, Elaine Huang, Shashwant Phuyal, Erisa Sula, Maria Lei Zhang, Cristian Loaiza, Erin Thorstensen, Keith Steiger, Katie Schum, Kayla Urbaez, Anna Ma, Annie Yang Weaver, Christopher Finch, PK Morrow, Mark Benton   +40 more
doaj   +1 more source

324 Allogeneic CAR T cells targeting Liv-1 for breast cancer

Journal for ImmunoTherapy of Cancer, 2023
Minh Pham, Jonathan Terrett, Demetrios Kalaitzidis, Jason Sagert, Lauren Zakas, Laura Bartle, Zejun Li, Kelly Maeng, Luke Hanley, Avanti Ganpule   +9 more
doaj   +1 more source

DeepFM-Crispr: Prediction of CRISPR On-Target Effects via Deep Learning [PDF]

arXiv
Since the advent of CRISPR-Cas9, a groundbreaking gene-editing technology that enables precise genomic modifications via a short RNA guide sequence, there has been a marked increase in the accessibility and application of this technology across various fields.
arxiv  

A bacterial gene-drive system efficiently edits and inactivates a high copy number antibiotic resistance locus. [PDF]

, 2019
Gene-drive systems in diploid organisms bias the inheritance of one allele over another. CRISPR-based gene-drive expresses a guide RNA (gRNA) into the genome at the site where the gRNA directs Cas9-mediated cleavage.
Bier, Ethan, Kulkarni, Surashree S, Nizet, Victor, Valderrama, J Andrés   +3 more
core   +1 more source

CRISPI: a CRISPR interactive database [PDF]

, 2009
Christine Rousseau, Mathieu Gonnet, M. Le Romancer, Jacques Nicolas   +3 more
openalex   +1 more source

High frequency CCR5 editing in human hematopoietic stem progenitor cells protects xenograft mice from HIV infection

Nature Communications
The only cure of HIV has been achieved in a small number of people who received a hematopoietic stem cell transplant (HSCT) comprising allogeneic cells carrying a rare, naturally occurring, homozygous deletion in the CCR5 gene. The rarity of the mutation
Daniel T. Claiborne, Zachary Detwiler, Steffen S. Docken, Todd D. Borland, Deborah Cromer, Amanda Simkhovich, Youdiil Ophinni, Ken Okawa, Timothy Bateson, Tao Chen, Wesley Hudson, Radiana Trifonova, Miles P. Davenport, Tony W. Ho, Christian L. Boutwell, Todd M. Allen   +15 more
doaj   +1 more source