Results 71 to 80 of about 315,823 (196)

274 Development of CTX112 a next generation allogeneic multiplexed CRISPR-edited CART cell therapy with disruptions of the TGFBR2 and Regnase-1 genes for improved manufacturing and potency

Journal for ImmunoTherapy of Cancer, 2023
Sarah Cohen, Jacob Waldman, Andrew Dunn, Thao Nguyen, Jonathan Terrett, Brigid Mcewan, Meghna Kuppuraju, Mohammed Ghonime, Robert Chain, Zinkal Padalia, Demetrios Kalaitzidis, Elizabeth Koch, Lauren Zakas, Nivedita Jaishankar, Davis Settipane, Paul Tetteh, Mary-Lee Dequeant, Sushant Karnik, Chandirasegaran Massilamany, Henia Dar, Melanie Allen, Laura Serwer, Melanie Butler-Gauthier, Parin Sripakdeevong, Shashwat Nagar, Yin Tang, Nicole Flanagan, Elaine Huang, Shashwant Phuyal, Erisa Sula, Maria Lei Zhang, Cristian Loaiza, Erin Thorstensen, Keith Steiger, Katie Schum, Kayla Urbaez, Anna Ma, Annie Yang Weaver, Christopher Finch, PK Morrow, Mark Benton   +40 more
doaj   +1 more source

CRISPR-Cas systems in multicellular cyanobacteria

, 2018
Novel CRISPR-Cas systems possess substantial potential for genome editing and manipulation of gene expression. The types and numbers of CRISPR-Cas systems vary substantially between different organisms.
Viktoria Reimann (5505170), Alicia M. Muro-Pastor (5505173), Wolfgang R. Hess (6801578), Manuel Brenes-Álvarez (5505176), Omer S. Alkhnbashi (5408990), Rolf Backofen (11285), Shengwei Hou (1458853)   +6 more
core   +1 more source

324 Allogeneic CAR T cells targeting Liv-1 for breast cancer

Journal for ImmunoTherapy of Cancer, 2023
Minh Pham, Jonathan Terrett, Demetrios Kalaitzidis, Jason Sagert, Lauren Zakas, Laura Bartle, Zejun Li, Kelly Maeng, Luke Hanley, Avanti Ganpule   +9 more
doaj   +1 more source

Delivering CRISPR: a review of the challenges and approaches

Drug Delivery, 2018
Gene therapy has long held promise to correct a variety of human diseases and defects. Discovery of the Clustered Regularly-Interspaced Short Palindromic Repeats (CRISPR), the mechanism of the CRISPR-based prokaryotic adaptive immune system (CRISPR ...
Christopher A. Lino, Jason C. Harper, James P. Carney, Jerilyn A. Timlin   +3 more
doaj   +1 more source

CRISPR to the Core [PDF]

The CRISPR Journal, 2020
openaire   +2 more sources

CRISPR-based drug target discovery : implications for CRISPR-based therapies

, 2022
The CRISPR system was discovered in prokaryotic cells, and it is now one of the most efficient molecular tools to modify genes in eukaryotic cells. It is widely used to inactivate or modify genes in cell lines, animal models, and is also used in several ...
Long Jiang (18682603)
core  

Genome editing from Cas9 to IscB: Backwards and forwards towards new breakthroughs

Engineering Microbiology, 2021
Zhenxiao Yu, Qunxin She
doaj   +1 more source

Comparative Analysis of Cell Dilution Assays for Single-Cell Colony Formation in CRISPR-Mediated Knockout Screening

Cyprus Journal of Medical Sciences
BACKGROUND/AIMS: The ribonucleic acid (RNA)-guided Cas9 nuclease from the microbial clustered regularly interspaced palindromic repeats (CRISPR) immune system enables genome editing in eukaryotic cells by using a 20-nucleotide target sequence guide RNA ...
Hülya Dönmez, Bahadır Batar, Burhan Turgut   +2 more
doaj   +1 more source

CRISPR-Associated Primase-Polymerases are implicated in prokaryotic CRISPR-Cas adaptation

, 2021
CRISPR-Cas pathways provide prokaryotes with acquired “immunity” against foreign genetic elements, including phages and plasmids. Although many of the proteins associated with CRISPR-Cas mechanisms are characterized, some requisite enzymes remain elusive.
Katerina Zabrady (5479505), Aidan Doherty (4461097), Matej Zabrady (5479511), Peter Kolesar (683818), Arthur Wing Hang Li (4466506)   +4 more
core  

EXPLAINABLE AND SECURE ARTIFICIAL INTELLIGENCE FRAMEWORKS FOR CRISPR GENOMICS: ADVANCES, LIMITATIONS, SIMULATION SYSTEMS, AND BLOCKCHAIN-ENABLED TRANSLATIONAL INTEGRATION

Journal of Bioinformatics and Genomics
Artificial intelligence (AI) has significantly accelerated CRISPR-Cas genome editing by improving guide RNA (gRNA) design, off-target prediction, DNA repair outcome estimation, and prime-editing optimization.
Raghu Ram Chowdary V., Raja Rao M.
doaj   +1 more source