Results 121 to 130 of about 321,595 (358)

Inhibiting CRISPR [PDF]

Nature Methods, 2019
openaire   +2 more sources

Genome engineering using the CRISPR-Cas9 system

Nature Protocols, 2013
F. Ran, P. Hsu, Jason B Wright, Vineeta Agarwala, Vineeta Agarwala, David A. Scott, Feng Zhang   +6 more
semanticscholar   +1 more source

Sculpting the Future of Bone: The Evolution of Absorbable Materials in Orthopedics

Advanced Materials, EarlyView.
This review summarizes the current status of polymeric, ceramic, and metallic absorbable materials in orthopedic applications, and highlights several innovative strategies designed to enhance mechanical performance, control degradation, and promote bioactivity. We also discuss the progress and translational potential of absorbable materials in treating
Zhao Wang, Zehui Lv, Xuejie Cai, Yingjie Wang, Bo Peng, Haojing Xu, Hualuo Pang, Xingdong Yang, Jiawei Xu, Yixin Bian, Bin Feng, Peng Wen, Yufeng Zheng, Xisheng Weng   +13 more
wiley   +1 more source

Demystification and feasibility of CRISPR technology and gene editing in African laboratories

Biology Open, 2023
Mohamed Jemaà
doaj   +1 more source

Potent Liver‐Tropic mRNA Lipid Nanoparticles: ApoE‐Mediated Delivery Through a Low‐Density Lipoprotein Receptor Independent Uptake Mechanism

Advanced Materials, EarlyView.
Helper and ionizable lipids play a crucial role in determining ApoE binding and subsequent liver tropism and LDLR‐mediated uptake. Ionizable lipids primarily govern the LDLR‐independent uptake pathway. This complementary interplay between lipid components ultimately governs LNP delivery performance and therapeutic efficacy in the liver.
Ashish Sarode, Christian Ortiz, Tadeh Derstepanian, Natalia Vargas‐Montoya, Priyal Patel, Nikita Khadse, Saikat Manna, Ryan Landis, Joseph Skaleski, Lianne Boeglin, Hongfeng Deng, Anusha Dias, Hong Wang, Debora Barreiros Petropolis, Barak Yahalom, Shrirang Karve, Frank DeRosa   +16 more
wiley   +1 more source

Episodic live imaging of cone photoreceptor maturation in GNAT2-EGFP retinal organoids

Disease Models & Mechanisms, 2023
Jinlun Bai, David S. Koos, Kayla Stepanian, Zachary Fouladian, Dominic W. H. Shayler, Jennifer G. Aparicio, Scott E. Fraser, Rex A. Moats, David Cobrinik   +8 more
doaj   +1 more source

Genome-Scale CRISPR-Cas9 Knockout Screening in Human Cells

Science, 2014
Ophir Shalem, Neville E. Sanjana, E. Hartenian, Xi Shi, David A. Scott, T. Mikkelsen, D. Heckl, B. Ebert, D. Root, John G Doench, Feng Zhang   +10 more
semanticscholar   +1 more source

Two‐Photon 3D Printing of Functional Microstructures Inside Living Cells

Advanced Materials, EarlyView.
This study demonstrates 3D printing inside living cells by using two‐photon photo‐lithography. A bio‐compatible photoresist is injected into cells and selectively polymerized with a femtosecond laser, creating custom‐shaped intracellular structures with submicron resolution.
Maruša Mur, Aljaž Kavčič, Uroš Jagodič, Rok Podlipec, Matjaž Humar   +4 more
wiley   +1 more source

Mechanism for Cas4-assisted directional spacer acquisition in CRISPR–Cas

, 2021
Chunyi Hu, Cristóbal Almendros, Ki Hyun Nam, Ana Rita Costa, Jochem N. A. Vink, Anna C. Haagsma, Saket R. Bagde, Stan J. J. Brouns, Ailong Ke   +8 more
openalex   +2 more sources

Epigenetic Events and Germ Line Transmission in Rag1 knock-out Chimeric Mice Produced by CRISPR/Cas9 Technology [PDF]

, 2021
Maryam Salimi, Maryam Mehravar, Abolfazl Shirazi, Ali Sarvari, Mohammad Mahdi Naderi, Ali Malekpour, Mohammad Mehdi Mehrazar, Mohammad Majidi, Bahareh Behzadi   +8 more
openalex   +1 more source