Results 141 to 150 of about 210,801 (263)

CRISPR and Fanzor in sickle cell disease: current progress and future prospects. [PDF]

Front Genome Ed
Alhumoudi AY, Alotaibi AG, Alosaimi NF, Alshalani A, Alqahtani SM, Alsaab SM, Almutiri BJ, Albariqi MMH.   +7 more
europepmc   +1 more source

Redox‐Dependent Chaperoning of GBF1 Condensates Regulates Seed Germination in Arabidopsis

Advanced Science, EarlyView.
In dormant seeds (low ROS), GBF1 forms liquid condensates to repress the germination gene CathB3, and the chaperone GIP1 maintains condensate liquidity and repressive activity. Upon imbibition (high ROS), ROS oxidize GIP1 during germination, impairing its chaperone function.
Yunying Wang, Xiaofeng Fang
wiley   +1 more source

Expanding the Microbial Genomic Landscape and Biotechnological Applications of CRISPR-Cas Systems. [PDF]

Biology (Basel)
Singh S, Tiwari H, Singh M, Gautam V, Gautam A, Gautam HK.   +5 more
europepmc   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Rapid Self-Selecting and Clone-Free Integration of Transgenes into Engineered CRISPR Safe Harbor Locations in Caenorhabditis elegans

G3: Genes, Genomes, Genetics, 2020
Zachary C. Stevenson, Megan J. Moerdyk-Schauwecker, Brennen Jamison, Patrick C. Phillips   +3 more
doaj   +1 more source

Contemporary Endothelial Genome Editing Technologies: Towards Precision Genetic Medicine for Vascular Diseases. [PDF]

Int J Mol Sci
Zhao YY, Evans CE.
europepmc   +1 more source

NUDT21 Drives T‐Cell Acute Lymphoblastic Leukemia Through Dual Regulation of Alternative Polyadenylation and Transcriptional Activation

Advanced Science, EarlyView.
In summary, our study defines a coordinated oncogenic model in which NUDT21 integrates alternative polyadenylation–dependent UBE2D3 stabilization and transcriptional activation to sustain MYC‐driven T‐ALL cell survival, thereby establishing NUDT21 as a central regulatory node and a promising therapeutic target.
Conglian Qiu, Jianwei Wang, Zhiheng Li, Qi Ji, Hui Zhang, Qinyi Zhang, Senlin Zhang, Juanjuan Yu, Yanfang Tao, Yijun Wu, Chunxia Shi, Zong Zai, Zimu Zhang, Yizhen Li, Zhenjiang Bai, Shaoyan Hu, Jian Pan, Yang Yang, Shuiyan Wu   +18 more
wiley   +1 more source

Assessment of a Split Homing Based Gene Drive for Efficient Knockout of Multiple Genes

G3: Genes, Genomes, Genetics, 2020
Nikolay P. Kandul, Junru Liu, Anna Buchman, Valentino M. Gantz, Ethan Bier, Omar S. Akbari   +5 more
doaj   +1 more source

Dissecting conserved molecular mechanisms of biological toxin activity through CRISPR screening. [PDF]

Biochem Soc Trans
Waller MA, D'Araujo TY, Denes CE, Neely GG.   +3 more
europepmc   +1 more source

Leveraging Macrophage Metabolic Reprogramming for Enhanced Anti‐Tumor Immunity

Advanced Science, EarlyView.
Tumor‐associated macrophages (TAMs) are key regulators of the tumor microenvironment (TME), with their metabolic states playing a critical role in tumor progression or regression. This review summarizes current understanding of TAM metabolic plasticity alongside cutting‐edge bioengineering innovations, outlining a roadmap for transforming the ...
Zhiyun Liu, Lingyao Zeng, Xulin Gan, Yilin Zhou, Han Shen, Dan Wu, Xin Shou, Minmin Jiang, Liyun Shi   +8 more
wiley   +1 more source