Results 161 to 170 of about 363,164 (302)

CRISPR-Cas9 Therapeutics in Early Clinical Development: Delivery and Molecular Diagnostics. [PDF]

Cells
Rutkowska A, Strózik T, Wasiak T, Ciunowicz D, Kapelan N, Szczepaniak N, Sosnowski J, Goślińska W, Bartkowiak J, Budny-Lewandowska A, Antończyk P, Markiewicz M, Gustaw P, Filiks K, Jaskólska M, Stoczyńska-Fidelus E.   +15 more
europepmc   +1 more source

Phase Separation of NFIB Suppresses SLC3A2‐Mediated Ferroptosis in Castration‐Resistant Prostate Cancer

Advanced Science, EarlyView.
Castration‐resistant prostate cancer (CRPC) remains sensitive to ferroptosis, but its intrinsic resistance is poorly understood. Here, we identify NFIB as a master suppressor. SIRT7‐mediated NFIB acetylation drives its liquid–liquid phase separation, which promotes SLC3A2 transcription to inhibit ferroptosis.
Qiunuo Li, Danyang Chen, Yongzhen Xia, Yili Long, Nan Huang, Rongna Li, Mengting Shi, Mairehaba Kadier, Huafeng Luo, Xiaohui Chen, Hao Liu, Guanmin Jiang   +11 more
wiley   +1 more source

CRISPR and the Promise of Gene Editing: Unlocking Curative Possibilities for Liver Disorders Worldwide. [PDF]

ACG Case Rep J
Kulsum S, Khan SA, Pinnam HS, Malik H, Ali H, Dahiya DS.   +5 more
europepmc   +1 more source

Understanding and Overcoming Antibody‐Drug Conjugate Resistance: Biological Mechanisms and Emerging Analytical Frameworks in Breast Cancer

Advanced Science, EarlyView.
Antibody–drug conjugates (ADCs) transform breast cancer therapy, yet resistance limits their durability. Emerging evidence reveals that ADC failure is not solely tumor‐intrinsic but shaped by dynamic tumor–microenvironment interactions that alter drug delivery, processing, and response.
Minji Seo, Jangsoon Lee, Naoto T. Ueno
wiley   +1 more source

From CRISPR functional genomics to synthetic interventions: engineering antiviral strategies. [PDF]

J Virol
Qiao W.
europepmc   +1 more source

Deciphering and Targeting the Schwannoma‐Neuron‐Macrophage Crosstalk for the Treatment of Schwannomatosis and Associated Pain

Advanced Science, EarlyView.
We established patient‐derived SWN cell lines and orthotopic PDX models that recapitulate patient pain phenotypes, alongside a novel intravital DRG imaging platform to track macrophage infiltration and neuronal pain responses. Using these models, we define HMGB1–CCL2–IL‐6 signaling crosstalk driving pain and identify EGF signaling as a key regulator of
Zhenzhen Yin, Limeng Wu, Yanling Zhang, Yao Sun, Grace Y. Lee, Simeng Lu, Xing Gao, John W. Chen, Sonu Subudhi, William Ho, Chao Zhu, Jun Ren, Gino B. Ferraro, Alona Muzikansky, Anat Stemmer‐Rachamimov, Jianren Mao, Scott R. Plotkin, Lei Xu   +17 more
wiley   +1 more source

Application of CRISPR/Cas13a system on the rapid detection of Salmonella spp. [PDF]

PLoS Negl Trop Dis
Huang Y, Liang W, Huang M, Deng Y, Huang Z, Ai C, Tan W, Jiang L.   +7 more
europepmc   +1 more source

Size‐Modulated Mesoderm‐Endoderm Divergence and Myocardial Cavitation in Micropatterned Cardioids

Advanced Science, EarlyView.
Micropatterned cardioids, CRISPR‐engineered reporter hiPSCs, deep‐tissue imaging, and single‐cell RNA sequencing are integrated to model mesoderm‐endoderm co‐development. Heart‐foregut crosstalk promotes single large cavitation inside cardioids, resembling early heart chamber formation. ABSTRACT The human heart, originating from the splanchnic mesoderm,
Plansky Hoang, David W. McKellar, Andrew Kowalczewski, Nhu Y. Mai, Meng Chai, Xiaojun L. Lian, Yi Zheng, Jeffrey Amack, Nathan Tucker, Iwijn De Vlaminck, Huaxiao Yang, Benjamin D. Cosgrove, Zhen Ma   +12 more
wiley   +1 more source

Activated PI3K delta syndrome 1 mutations cause neutrophilia in zebrafish larvae

Disease Models & Mechanisms, 2023
Stone Elworthy, Holly A. Rutherford, Tomasz K. Prajsnar, Noémie M. Hamilton, Katja Vogt, Stephen A. Renshaw, Alison M. Condliffe   +6 more
doaj   +1 more source

Rapid identification of African swine fever virus in diagnostic samples using CRISPR-Cas. [PDF]

J Vet Diagn Invest
Kambakam S, Thomas J, Robbe-Austerman S, Shanmuganatham K, Palinski R.   +4 more
europepmc   +1 more source