Results 131 to 140 of about 321,595 (358)
Cpf1 Is a Single RNA-Guided Endonuclease of a Class 2 CRISPR-Cas System
Cell, 2015 Bernd Zetsche +11 more
semanticscholar +1 more source
Advanced Materials Technologies, EarlyView.This review explores the integration of microfluidic technology with organoid systems as an innovative platform for studying menopausea complex multi‐organ condition. By enabling precise simulation of inter‐organ communication and hormone responses, microfluidic organoids offer a physiologically relevant model for investigating menopausal syndrome and ...
Qianyi Zhang +4 more
wiley +1 more source
Efficient mouse genome engineering by CRISPR-EZ technology
, 2018 A Modzelewski +5 more
openalex +2 more sources
Advanced Robotics Research, EarlyView.Gut microbiota and biomarkers are linked to diseases like neurological disorders and metabolic syndromes. Ingestible capsule robots enable minimally invasive gut health assessment. This article proposes a promising direction for the advancement of capsule robots, integrating in situ sampling, real‐time diagnostics, and personalized therapy.
Xizong Chen +3 more
wiley +1 more source
A functional sgRNA-CRISPR screening method for generating murine RET and NTRK1 rearranged oncogenes
Biology Open, 2023 Laura Schubert +7 more
doaj +1 more source
A target expression threshold dictates invader defense and prevents autoimmunity by CRISPR-Cas13
, 2022 Elena Vialetto +5 more
openalex +2 more sources
Advanced Science, EarlyView.YAP undergoes phase separation to activate the AJUBA super‐enhancer, driving aberrant mitosis through spindle checkpoint dysregulation in breast cancer. This study uncovers a mechanistic link between YAP condensates, super‐enhancer activation, and aneuploidy formation.
Rui Zhang +8 more
wiley +1 more source
Optimization of CRISPR/Cas9 Delivery to Human Hematopoietic Stem and Progenitor Cells for Therapeutic Genomic Rearrangements [PDF]
, 2018 Annalisa Lattanzi +14 more
openalex +1 more source
NARFL Knockout Triggers Ferroptosis‐Driven Vascular Endothelial Dysfunction
Advanced Science, EarlyView.NARFL is vital for CIA and oxidative stress resistance. NARFL deletion in HPMEC cells, zebrafish, and mice is lethal and rescued by a Ferroptosis inhibitor. NARFL deficiency disrupted its interaction with CIA proteins, decreased aconitase activity, increased IRP1 activity, induced Fe overload, and led to ferroptosis and oxidative stress, resulting in ...
Hui Hu +15 more
wiley +1 more source