Results 171 to 180 of about 358,486 (301)

CRISPR-Cas is beneficial in plasmid competition, but limited by competitor toxin-antitoxin activity when horizontally transferred. [PDF]

PLoS Biol
Sünderhauf D, Ringger JR, Payne LJ, Pinilla-Redondo R, Gaze WH, Brown SP, van Houte S.   +6 more
europepmc   +1 more source

My CRISPR Book [PDF]

The CRISPR Journal, 2020
openaire   +2 more sources

IGF‐1 Deficiency Serves as an Integrated Biomarker Pathogenic Driver and Predictor in Poor Ovarian Response

Advanced Science, EarlyView.
IGF‐1 deficiency underlies poor ovarian response (POR), as reduced levels in follicular fluid and granulosa cells impair antral follicle formation and compromise reproductive outcomes. Including IGF‐1 as a biomarker significantly enhances the accuracy of models predicting both PORrisk and pregnancy success.
Zhu Hu, Yuanyuan Yu, Guanyou Huang, Jinnan Li, Chao Yang, Aizhuan Long, Jia Tang, Tengxiang Chen, Shuyun Zhao, Tuo Zhang   +9 more
wiley   +1 more source

CRISPR-based diagnostics for infectious diseases: mechanisms, advancements and clinical transformation prospects. [PDF]

Front Cell Infect Microbiol
Pan Z, Xu L, Fan Z, Cao Y, Ren F.
europepmc   +1 more source

Programmable Klebsiella pneumoniae Phage Tropism Enabled by Scalable Receptor‐Binding Protein Mining and Modular Assembly

Advanced Science, EarlyView.
This work introduces a scalable, data‐driven strategy that turns the vast sequence diversity of phage receptor‐binding proteins into modular tools for engineering customizable phages. By clustering and experimentally validating diverse RBPs, the authors build an accurate map linking sequence to host specificity and create plug‐and‐play modules that ...
Shisong Jing, Yiyao Song, Xianbiao Bi, Yuqin Song, Dawei Wei, Jiangqing Huang, Yuan Zeng, Gang Zhang, Rong Zhang, Chao Wang, Jie Feng   +10 more
wiley   +1 more source

CRISPR/Cas Genome Editing and Its Applications in Cereal Crop Improvement. [PDF]

Plant Environ Interact
Kaniganti S, Saini H, Chaitanya AK, Hegde N, Shah P, Magar ND, Rijal R, Kaushik JJ, Nanda D, Sachan S, Kumar A, Bhoite R, Jamedar HR.   +12 more
europepmc   +1 more source

Sulfakinin Signaling Sense Circulating Fructose and Suppresses Food Consumption via Insulin‐Like Peptide in Bactrocera Dorsalis

Advanced Science, EarlyView.
This study discovered a new pathway that tells fruit flies when to stop eating. It found that rising blood sugar (fructose) is detected by a sensor called GR43a. This triggers a chain reaction involving the satiety signal sulfakinin and its receptor, ultimately activating a final satiety signal, ILP5.
Hong‐Fei Li, Bao Dong, Zheng‐Lin Ren, Xue‐Guang Zhu, Quan Lei, Yoonseong Park, Jin‐Jun Wang, Hong‐Bo Jiang   +7 more
wiley   +1 more source

Rapid Self-Selecting and Clone-Free Integration of Transgenes into Engineered CRISPR Safe Harbor Locations in Caenorhabditis elegans

G3: Genes, Genomes, Genetics, 2020
Zachary C. Stevenson, Megan J. Moerdyk-Schauwecker, Brennen Jamison, Patrick C. Phillips   +3 more
doaj   +1 more source

Commentary: CRISPR-Cas systems against carbapenem resistance-from proof-of-concept to clinical translation. [PDF]

Front Microbiol
D J, Mulavagili S, Vijayasimha M.
europepmc   +1 more source

NPM1 Mediates mRNA Sorting into Extracellular Vesicles via Specific RNA Motif Binding and Phase Separation

Advanced Science, EarlyView.
NPM1 selectively sorts specific mRNAs into extracellular vesicles (EVs) by recognizing RNA motifs and forming phase‐separated condensates. These mRNA cargos—including EGFR—are then loaded via multivesicular bodies. This active sorting pathway, validated in EVs derived from both lung cancer cells and patient serum, reveals a specific mechanism for ...
Kaixiang Zhang, Gaoge Sun, Xiangzheng Liu, Shuai Zuo, Pengyuan Wang, Boxiao Zhan, Zhi John Lu, Hang Yin, Ying Zhang   +8 more
wiley   +1 more source