Results 191 to 200 of about 321,595 (358)
The complexity of multiple CRISPR arrays in strains with (co-occurring) CRISPR systems. [PDF]
MicrolifeFehrenbach A +3 more
europepmc +1 more source
SAGES1: Clinical Translation of CRISPR Genome Editing Strategy to Induce Fetal Hemoglobin to Treat Sickle Cell Disease [PDF]
Rachel M. Levine +25 more
openalex +1 more source
Lactylation‐Driven YTHDC1 Alleviates MASLD by Suppressing PTPN22‐Mediated Dephosphorylation of NLRP3
Advanced Science, EarlyView.In MASLD, YTHDC1 undergoes increased lactylation and ubiquitination, reducing its expression. AARS1 mediates lactylation at lysine 565, while disrupted binding to LDHA further promotes lactylation, suppressing YTHDC1. This downregulation enhances PTPN22 mRNA stability, leading to NLRP3 dephosphorylation and activation, which exacerbates inflammation ...
Feng Zhang +16 more
wiley +1 more source
CRISPR-Cas9 Gene Editing in <i>Aspergillus</i>: From Pathogenesis to Metabolic Engineering. [PDF]
Biology (Basel)Hu D, Zhao R, Lin Y, Jiang C.
europepmc +1 more source
Exploiting CRISPR-Cas to manipulate Enterococcus faecalis populations
, 2017 Karthik Hullahalli +2 more
openalex +1 more source
ZFN, TALEN, and CRISPR/Cas-based methods for genome engineering.
Trends in Biotechnology, 2013 T. Gaj, C. Gersbach, C. Barbas
semanticscholar +1 more source
CD168 Identifies Proliferating Pancreatic Islet Cells in Murine and Human
Advanced Science, EarlyView.This study identifies CD168 as a conserved surface marker for proliferating β‐cells in mouse, human islets, and pancreatic islet tumors. CD168⁺ cells show high proliferation and low insulin expression. CD168+ cells form mostly uni‐β lineage clones, and some of the clones are multi‐lineage.
Shubo Yuan +21 more
wiley +1 more source
Chronic In Vivo CRISPR-Cas Genome Editing: Challenges, Long-Term Safety, and Outlook. [PDF]
CellsBao C +6 more
europepmc +1 more source