Results 211 to 220 of about 321,595 (358)

C2c2 is a single-component programmable RNA-guided RNA-targeting CRISPR effector

Science, 2016
Omar O. Abudayyeh, J. Gootenberg, S. Konermann, J. Joung, I. Slaymaker, David B. T. Cox, Sergey A. Shmakov, K. Makarova, E. Semenova, L. Minakhin, K. Severinov, A. Regev, E. Lander, E. Koonin, Feng Zhang   +14 more
semanticscholar   +1 more source

The Disordered Region of ASXL1 Acts as an Auto‐Regulator Through Condensation

Advanced Science, EarlyView.
ASXL1's long IDR encodes an electrostatic “basic platform + acidic brake” that autoregulates condensation. Truncation at a clinical hotspot lifts this brake, forming condensates that retarget BRD2, remodel local chromatin accessibility, and impair neutrophil maturation.
Xiao Fang, Qiwei Li, Wenqing Zhang
wiley   +1 more source

The Emergence of a CRISPR-Cas Revolution in Ecology: Applications, Challenges, and an Ecologist's Overview of the Toolbox. [PDF]

Mol Ecol Resour
Plewnia A, Hoenig BD, Lötters S, Heine C, Erens J, Böning P, Bending GD, Krehenwinkel H, Williams MA.   +8 more
europepmc   +1 more source

Cas12b-assisted one-step dual-target CRISPR system for Mycobacterium tuberculosis detection

Xike Zhou, Xuchun Han, Lifang Liu, Xiaoping Wang, Jackson G. Lu, Long Qiu, Tao Wu, Hao Pei, Guomin Zhao, Jin Wang   +9 more
openalex   +1 more source

Multiple Stepwise Gene Knockout Using CRISPR/Cas9 in Escherichia coli

, 2018
Enrico König, Francesca Zerbini, Ilaria Zanella, Davide Fraccascia, Guido Grandi   +4 more
openalex   +2 more sources

Clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein 9 with improved proof-reading enhances homology-directed repair [PDF]

, 2018
Tomoko Kato-Inui, Gou Takahashi, Szuyin Hsu, Yuichiro Miyaoka   +3 more
openalex   +1 more source

Molecular mechanism of active Cas7-11 in processing CRISPR RNA and interfering target RNA

, 2022
Hemant N. Goswami, Jay Rai, Anuska Das, Hong Li   +3 more
openalex   +1 more source

CRISPR-Mediated Modular RNA-Guided Regulation of Transcription in Eukaryotes

Cell, 2013
Luke A. Gilbert, Matthew H. Larson, Leonardo Morsut, Zairan Liu, G. Brar, S. E. Torres, Noam Stern-Ginossar, Onn Brandman, E. Whitehead, J. Doudna, W. Lim, J. Weissman, Lei S. Qi   +12 more
semanticscholar   +1 more source

Allelic Variation in Maize Malate Dehydrogenase 7 Shapes Promoter Methylation and Banded Leaf and Sheath Blight Resistance

Advanced Science, EarlyView.
In this study maize chloroplastic malate dehydrogenase7 (ZmMDH7), is identified as a Rhizoctonia solani resistance gene in maize. ZmMDH7 is regulated by transcription factor ZmWRKY44 via pathogens challenge to elevate mitochondrial ROS and SA signaling pathway.
Luyang Wei, Junbin Chen, Chuang Liu, DanDan Liu, Meida Du, Shengfeng He, Wenyu Cheng, Vijai Bhadauria, You‐Liang Peng, Wangsheng Zhu   +9 more
wiley   +1 more source

CRISPR/Cas9-based programmable genome editing in chickens: concepts, applications and regulatory issues. [PDF]

Front Genome Ed
Kolluri G, Naim A, Kumar Kurva S, Tyagi JS, Ansari MM, Tomar S, Tiwari AK, Chouhan L.   +7 more
europepmc   +1 more source