Results 211 to 220 of about 333,510 (359)

Genome editing from Cas9 to IscB: Backwards and forwards towards new breakthroughs

Engineering Microbiology, 2021
Zhenxiao Yu, Qunxin She
doaj  

Meisoindigo Acts as a Molecular Glue to Target PKMYT1 for Degradation in Chronic Myeloid Leukemia Therapy

Advanced Science, EarlyView.
Meisoindigo targets PKMYT1 for degradation by acting as a molecular glue that enhances PKMYT1‐TRIM25 interaction, leading to K48‐linked ubiquitination and subsequent proteasomal degradation, thereby exerting therapeutic effects in chronic myeloid leukemia.
Zhao‐Xin Zhang, Shu‐Ying Li, Fang‐Fei Li, Qin‐Yan Shi, Cheng‐Yong Tan, Xiao‐Jing Wang, Mi Li, Yun‐Bao Liu, Jing Jin, Yong Li, Shi‐Shan Yu   +10 more
wiley   +1 more source

Faculty Opinions recommendation of Sequence- and structure-specific RNA processing by a CRISPR endonuclease.

, 2010
Robert Batey
openalex   +2 more sources

The impact of CRISPR repeat sequence on structures of a Cas6 protein–RNA complex [PDF]

, 2012
Ruiying Wang, Han Zheng, G. Preamplume, Yaming Shao, Hong Li   +4 more
openalex   +1 more source

Assessment and Mitigation of CRISPR‐Cas9‐Induced Nontargeted Translocations

Advanced Science, EarlyView.
Various inverted repeat elements are dispersed throughout genomes. This study reveals that these elements can cause significant chromosomal rearrangements when CRISPR editing occurs in their proximity. The risk can be mitigated by incorporating inverted repeat‐homologous segments into the CRISPR system, which represents a promising strategy for ...
Zhiyang Hou, Qiyi Yi, Mengying Wu, Lijun Wu, Fanghua Li, Ting Wang, Po Bian   +6 more
wiley   +1 more source

Characterization of CRISPR RNA Biogenesis and Cas6 Cleavage-Mediated Inhibition of a Provirus in the Haloarchaeon Haloferax mediterranei [PDF]

, 2012
Ming Li, Haibo Liu, Jun Han, Jun Liu, Rui Wang, Dahe Zhao, Jumin Zhou, Zhonghuai Xiang   +7 more
openalex   +1 more source

MRAS: Master Regulator Analysis of Alternative Splicing

Advanced Science, EarlyView.
This study developed a computational approach called MRAS, designed to identify master regulators of splicing differences across various biological contexts. In this framework, altered RBP expression, rather than spliceosomal mutations or other modifications, plays a central role in driving these splicing differences.
Lei Zhou, Yue Huang, Yang Zhao, Dan Guo, Xiao Wen, Ruihong Xu, Xuan Lv, Song Wu, Sicheng Jing, Zhaoqi Liu   +9 more
wiley   +1 more source

Universal Amplification-Free RNA Detection by Integrating CRISPR-Cas10 with Aptameric Graphene Field-Effect Transistor. [PDF]

Nanomicro Lett
Sun M, Yu Z, Wang S, Qiu J, Huang Y, Chen X, Zhang Y, Wang C, Zhang X, Liang Y, Liu H, She Q, Zhang Y, Han L.   +13 more
europepmc   +1 more source

Defense Systems Up: Structure of Subtype I-C/Dvulg CRISPR/Cas [PDF]

, 2012
N. LaRonde-LeBlanc
openalex   +1 more source

Engineering the Immune Response to Biomaterials

Advanced Science, EarlyView.
This paper reviews immune responses to biomaterials, stages of evolution in relation to managing these responses ranging from preventing to modulating them. It also discusses state‐of‐the‐art strategies to modulate these responses and modes of their delivery.
Abolfazl Salehi Moghaddam, Mehran Bahrami, Einollah Sarikhani, Rumeysa Tutar, Yavuz Nuri Ertas, Faleh Tamimi, Ali Hedayatnia, Clotilde Jugie, Houman Savoji, Asma Talib Qureshi, Muhammad Rizwan, Chima V. Maduka, Nureddin Ashammakhi   +12 more
wiley   +1 more source