Results 241 to 250 of about 333,510 (359)

Genome Engineering ofDrosophilawith the CRISPR RNA-Guided Cas9 Nuclease [PDF]

, 2013
Scott J. Gratz, Alexander M Cummings, Jennifer N. Nguyen, Danielle C. Hamm, Laura K. Donohue, Melissa M. Harrison, Jill Wildonger, Kate M. O’Connor-Giles   +7 more
openalex   +1 more source

Enhancer Extrachromosomal Circular DNA ANKRD28 Elicits Drug Resistance via POU2F2‐Mediated Transcriptional Network in Multiple Myeloma

Advanced Science, EarlyView.
Enhancer eccANKRD28‐manipulated MM cells have been demonstrated to facilitate drug resistance and promote MM progression by activating the key transcription factor, POU2F2. POU2F2 interacts with sequence‐specific eccANKRD28 as well as RUNX1 and RUNX2 motifs to form the protein complex, which activates the promoter of oncogenes (IRF4, JUNB, IKZF3, et al.
Binzhen Chen, Jia Liu, Yaoxin Zhang, Changming Shi, Di Zhu, Guoqiang Zhang, Fei Xiao, Lu Zhong, Minyue Zhang, Lai Guan Ng, Honghui Huang, Tingting Lu, Jian Hou   +12 more
wiley   +1 more source

Amplification-Free Electrochemiluminescent Biosensor for Ultrasensitive Detection of <i>Fusobacterium nucleatum</i> Using Tetrahedral DNA-Based CRISPR/Cas12a. [PDF]

Cyborg Bionic Syst
Zhang X, Wu M, Shi H, Kim S, Lu S, Wang P, Qin J.   +6 more
europepmc   +1 more source

Erwinia amylovora CRISPR Elements Provide New Tools for Evaluating Strain Diversity and for Microbial Source Tracking

, 2012
Gayle C. McGhee, George W. Sundin
openalex   +2 more sources

Correction of a Genetic Disease in Mouse via Use of CRISPR-Cas9 [PDF]

, 2013
Yuxuan Wu, Dan Liang, Yinghua Wang, Meizhu Bai, Wei Tang, Shiming Bao, Zhiqiang Yan, Dangsheng Li, Jinsong Li   +8 more
openalex   +1 more source

SSRP1/SLC3A2 Axis in Arginine Transport: A New Target for Overcoming Immune Evasion and Tumor Progression in Peripheral T‐Cell Lymphoma

Advanced Science, EarlyView.
Enhanced arginine uptake is a critical feature of metabolic reprogramming in PTCL, characterized by elevated expression of the arginine transporter SLC3A2. SLC3A2‐mediated arginine uptake facilitates PTCL proliferation and survival by enhancing OXPHOS metabolism and inducing immune evasion.
Yimin Ren, Lei Fan, Ling Wang, Yanping Liu, Jie Zhang, Boya Wang, Ruize Chen, Xiao Chen, Lingyu Zhuang, Yaping Zhang, Handong Sun, Jianyong Li, Wenyu Shi, Hui Jin   +13 more
wiley   +1 more source

Reinvigorating AMR resilience: leveraging CRISPR-Cas technology potentials to combat the 2024 WHO bacterial priority pathogens for enhanced global health security-a systematic review. [PDF]

Trop Med Health
Okesanya OJ, Ahmed MM, Ogaya JB, Amisu BO, Ukoaka BM, Adigun OA, Manirambona E, Adebusuyi O, Othman ZK, Oluwakemi OG, Ayando OD, Tan MIRS, Idris NB, Kayode HH, Oso TA, Ahmed M, Kouwenhoven MBN, Ibrahim AM, Lucero-Prisno DE.   +18 more
europepmc   +1 more source

Targeting PTBP3‐Mediated Alternative Splicing of COX11 Induces Cuproptosis for Inhibiting Gastric Cancer Peritoneal Metastasis

Advanced Science, EarlyView.
The splicing factor PTBP3 promotes COX11 exon skipping, allowing gastric cancer organoids to evade cuproptosis. Antisense oligonucleotide drugs targeting PTBP3‐mediated COX11 alternative splicing, in combination with copper ionophores, promote cuproptosis in organoids, thereby providing a therapeutic approach for gastric cancer peritoneal metastasis ...
Yajing Zhou, Chao Dong, Xiaochun Shen, Pengbo Wang, Tao Chen, Weikang Li, Xiaotong Sun, Peiyuan Li, Chengxiang Xu, Kaipeng Duan, Dongbao Li, Jin Zhou   +11 more
wiley   +1 more source

A tube-based biosensor for DNA and RNA detection. [PDF]

Sci Adv
Sun Y, Liu K, Zhang H, Zhao Y, Wen J, Zhao M, Li X, Li Z.   +7 more
europepmc   +1 more source

Specific Detection of Enteroaggregative Hemorrhagic Escherichia coli O104:H4 Strains by Use of the CRISPR Locus as a Target for a Diagnostic Real-Time PCR

, 2012
Sabine Delannoy, Lothar Beutin, Ylanna Kelner Burgos, Patrick Fach   +3 more
openalex   +1 more source