Results 241 to 250 of about 321,595 (358)

Soybean Auxin Transporter PIN3 Regulates Nitrate Acquisition to Improve Nitrogen Use and Seed Traits

Advanced Science, EarlyView.
Xu et al. discovers that switching off auxin transporters in soybean, PIN3a and PIN3b, disrupts auxin flow; this triggers ARF‐STF3/4 signal cascade to activate the nitrate importer NPF2.13 and soil nitrogen acquisition. Multi‐year field trials show edited soybeans maintain yield with higher oil content, offering a potential genetic route to improve ...
Huifang Xu, Shiyu Huang, Jie Wang, Tian Wang, Qingqing Han, Kexin Wu, Zhen Gao, Xiaolei Shi, Tianli Tu, Ming Wang, Laimei Huang, Jiaomei Chen, Yunqi Liu, Yumei Zhang, Guoqiang Lin, Zhichang Chen, Xu Chen   +16 more
wiley   +1 more source

Functional Coupling and Evolutionary Relationships Between Toxin-Antitoxin Systems and CRISPR-Cas Systems. [PDF]

Toxins (Basel)
Meng Y, Chen J, Liu L.
europepmc   +1 more source

A genome wide CRISPR screen reveals novel determinants of long-lived plasma cell secretory capacity [PDF]

Lucas J. D’Souza, Jennifer J. Young, Heather Coffman, Edward P. Petrow, Deepta Bhattacharya   +4 more
openalex   +1 more source

RNA editing with CRISPR-Cas13

Science, 2017
David B. T. Cox, J. Gootenberg, Omar O. Abudayyeh, B. Franklin, M. Kellner, J. Joung, Feng Zhang   +6 more
semanticscholar   +1 more source

Lipid Droplet‐Localized Spindle Apparatus Coiled‐Coil Protein 1 Regulates Lipid Droplet Distribution

Advanced Science, EarlyView.
SPDL1‐L, a long isoform of SPDL1, is identified as a bona fide lipid droplet‐associated protein that acts as a dynein adaptor to drive perinuclear clustering of lipid droplets. By linking lipid droplets to the microtubule network, SPDL1‐L extends the function of SPDL1 beyond mitosis and contributes to lipid droplet organization and nuclear remodeling ...
Honggang Su, Huimin Pan, Yaqiang Liu, Wei Wang, Yang Jiao, Yumo Hang, Xiahe Huang, Yong E. Zhang, Yuhang Chen, Mei Ding, Xun Huang   +10 more
wiley   +1 more source

A Rapid and Sensitive CRISPR-Cas12a for the Detection of <i>Legionella pneumophila</i>. [PDF]

Pol J Microbiol
Li J, Wang X, Wang X, Qu H, Gao L, Zhao Z, Luo P, Zheng Y.   +7 more
europepmc   +1 more source

The CRISPR/Cas9 induces large genomic fragment deletions of MSTN and phenotypic changes in sheep

, 2020
Yi Ding, Shiwei Zhou, Qiang Ding, Bei Cai, Xiaoe Zhao, Shu Zhong, Miaohan Jin, Xiaolong Wang, Baohua Ma, Yulin Chen   +9 more
openalex   +1 more source

Small Nucleolar RNA Snord17 Promotes Self‐Renewal of Intestinal Stem Cells through Yy2 mRNA Export and Tead4 Activation

Advanced Science, EarlyView.
Snord17, through interaction with Thoc3, promotes nuclear export and translation of Yy2 mRNA in Snord17+/+ ISCs. The Yy2 protein subsequently binds the Tead4 promoter to promote its transcription, activating Hippo signaling, which is essential for ISC maintenance.
Peikang Zhang, Yuwei Xu, Yufei Lan, Zhen Xiong, Zhibin Yi, Runyuan Wu, Cunzhen Li, Ying Du, Hui Guo, Yingchi Yang, Zusen Fan   +10 more
wiley   +1 more source

Spatiotemporally regulated mitochondrial genome editing <i>via</i> enzyme and NIR-activated CRISPR/Cas9 nanoplatform. [PDF]

Chem Sci
Yang F, Ran Q, Chen J, Bao G, Xian Y, Zhang C.   +5 more
europepmc   +1 more source

Targeting WEE1 in ARID1A/TP53 Concurrent Mutant Colorectal Cancer by Exploiting R‐Loop Accumulation and DNA Repair Deficiencies

Advanced Science, EarlyView.
ARID1A, a SWI/SNF complex component, is frequently mutated in colorectal cancer (CRC). CRC with ARID1A/TP53 concurrent mutations shows marked sensitivity to WEE1 inhibition. ARID1A loss induces R‐loop‐mediated replication stress, impairs ATF3 transcription, and amplifies WEE1i‐induced DNA damage, suggesting a promising therapeutic vulnerability ...
Chi Zhang, Yanjing Zhu, Luoyan Ai, Jingyuan Wang, Shan Yu, Yichen Wang, Xiaojing Xu, Mengling Liu, Yiyi Yu, Mengxuan Zhu, Yutong Liu, Zhenghang Xu, Haojie Zhou, Huishan Li, Qihong Huang, Qing Liu, Ke Peng, Tianshu Liu   +17 more
wiley   +1 more source