Results 321 to 330 of about 321,595 (358)
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Neuron, 2023
Genome engineering technologies provide an entry point into understanding and controlling the function of genetic elements in health and disease. The discovery and development of the microbial defense system CRISPR-Cas yielded a treasure trove of genome engineering technologies and revolutionized the biomedical sciences.
Georgios Kalamakis, Randall J. Platt
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Genome engineering technologies provide an entry point into understanding and controlling the function of genetic elements in health and disease. The discovery and development of the microbial defense system CRISPR-Cas yielded a treasure trove of genome engineering technologies and revolutionized the biomedical sciences.
Georgios Kalamakis, Randall J. Platt
openaire +2 more sources
Methods, 2020
Clustered regularly interspaced short palindromic repeats (CRISPR) and their associated proteins (Cas) are essential genetic elements in many archaeal and bacterial genomes, playing a key role in a prokaryote adaptive immune system against invasive foreign elements.
Alkhnbashi, Omer S. +4 more
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Clustered regularly interspaced short palindromic repeats (CRISPR) and their associated proteins (Cas) are essential genetic elements in many archaeal and bacterial genomes, playing a key role in a prokaryote adaptive immune system against invasive foreign elements.
Alkhnbashi, Omer S. +4 more
openaire +3 more sources
Nature Microbiology, 2018
CRISPR immunity begins with the acquisition of sequences from invading nucleic acids through spacer integration into a CRISPR locus. Off-target integration of spacers into other parts of the genome is now implicated as a spontaneous source of new CRISPR loci.
Alireza, Edraki, Erik J, Sontheimer
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CRISPR immunity begins with the acquisition of sequences from invading nucleic acids through spacer integration into a CRISPR locus. Off-target integration of spacers into other parts of the genome is now implicated as a spontaneous source of new CRISPR loci.
Alireza, Edraki, Erik J, Sontheimer
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Communications of the ACM, 2018
Considering a potential platform candidate in the evolving realm of gene-editing technologies research.
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Considering a potential platform candidate in the evolving realm of gene-editing technologies research.
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CRISPR-GPT for agentic automation of gene-editing experiments.
Nature Biomedical EngineeringPerforming effective gene-editing experiments requires a deep understanding of both the CRISPR technology and the biological system involved. Meanwhile, despite their versatility and promise, large language models (LLMs) often lack domain-specific ...
Yuanhao Qu +13 more
semanticscholar +1 more source
2019
Gene editing has great therapeutic impact, being of interest for many scientists worldwide. Clustered regularly interspaced short palindromic repeats (CRISPR) technology has been adapted for gene editing to serve as an efficient, rapid, and cost-effective tool.
Maria, Pallarès Masmitjà +2 more
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Gene editing has great therapeutic impact, being of interest for many scientists worldwide. Clustered regularly interspaced short palindromic repeats (CRISPR) technology has been adapted for gene editing to serve as an efficient, rapid, and cost-effective tool.
Maria, Pallarès Masmitjà +2 more
openaire +2 more sources
Genome editing with CRISPR–Cas nucleases, base editors, transposases and prime editors
Nature Biotechnology, 2020Andrew V. Anzalone +2 more
semanticscholar +1 more source
Science, 2019
Editing of plant, animal, and human genomes has never been easier, as this country's scientists are rapidly demonstrating.
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Editing of plant, animal, and human genomes has never been easier, as this country's scientists are rapidly demonstrating.
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The new frontier of genome engineering with CRISPR-Cas9
Science, 2014J. Doudna, E. Charpentier
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