Results 71 to 80 of about 10,271,382 (298)

Non-targeted screening and characterization of organic pollutants in wastewater from an industrial park in China

Emerging Contaminants
Industrial parks are significant sources of complex water pollution, making it challenging to trace pollutant origins and ensure water quality. This study established a non-targeted screening workflow and compound persistence, mobility, and toxicity (PMT)
Xu Tan, Shanwei Sun, Song Hou, Linlin Wu, Yangwei Bai, Hongbo Xi, Jian Xu, Changsheng Guo   +7 more
doaj   +1 more source

A Framework for Ecotoxicity Testing in the 21st Century: Ecotox21

Applied Sciences, 2019
To reduce the considerable investments of toxicity testing and protecting animal welfare, a new toxicity testing strategy based on response pathways of human cell lines has been proposed in the United States to evaluate the chemical exposure risks to ...
Zhen-guang Yan, Xin Zheng, Fu Gao, Jun-tao Fan, Shu-ping Wang, Li-xin Yang   +5 more
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Advances and Challenges in Understanding Atmospheric Oxidizing Capacity in China: Insights from Chemical Mechanisms and Model Applications

Toxics
The ability of the atmosphere to convert primary pollutants into secondary pollutants through atmospheric oxidants is referred to as the atmospheric oxidizing capacity (AOC).
Peixuan Li, Yanqin Ren, Fang Bi, Fangyun Long, Junling Li, Haijie Zhang, Zhenhai Wu, Hong Li   +7 more
doaj   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Pollution Characterization and Environmental Impact Evaluation of Atmospheric Intermediate Volatile Organic Compounds: A Review

Toxics
Atmospheric intermediate volatile organic compounds (IVOCs) are important precursors of secondary organic aerosols (SOAs), and in-depth research on them is crucial for atmospheric pollution control.
Yongxin Yan, Yan Nie, Xiaoshuai Gao, Xiaoyu Yan, Yuanyuan Ji, Junling Li, Hong Li   +6 more
doaj   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Comparison of Population-Weighted Exposure Estimates of Air Pollutants Based on Multiple Geostatistical Models in Beijing, China

Toxics
Various geostatistical models have been used in epidemiological research to evaluate ambient air pollutant exposures at a fine spatial scale. Few studies have investigated the performance of different exposure models on population-weighted exposure ...
Yinghan Wu, Jia Xu, Ziqi Liu, Bin Han, Wen Yang, Zhipeng Bai   +5 more
doaj   +1 more source

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source

Flying qualities criteria for superaugmented aircraft [PDF]

, 1984
An overview of Dryden superaugmented aircraft flying qualities research is presented. This includes F-8 digital fly by wire flight experiments, orbiter flying qualities, shuttle improvements, AFTI/F-16, flying qualities and control system alternatives ...
Berry, D. T.
core   +1 more source