Results 91 to 100 of about 5,414,012 (318)
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
AgricultureFood waste is commonly valorized through aerobic composting, yet the responses of water-soluble organic carbon (WSOC) across molecular-weight (MW) fractions remain insufficiently resolved.
Lishi Tang +5 more
doaj +1 more source
Journal of MultiDisciplinary Evaluation, 1978 Originally published as Paper #10, Occasional Paper Series, December, 1977 * This monograph was prepared under a grant from the Carnegie Corporation. Mary Lee Smith contributed at every stage of the preparation of this monograph; reading the literature, developing the ideas, outlining and editing the final product. Nancy W.
openaire +2 more sources
Relevance Criteria Used by Teachers in Selecting Oral History Materials [PDF]
, 2005 From a user-centered and task-specific perspective on relevance, we studied the relevance criteria used by teachers - an understudied but important group - who were searching for materials to use in the classroom to support learning on a particular theme.
Lawley, Katy Newton +2 more
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Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
GCAP Marking Criteria and Guidance
, 2011 This document is the King's Learning institute Graduate Certificate in Academic Practice (GCAP) Marking Criteria and Guidance that was used in the GCAP programme in 2008-9 academic year.
King's Learning Institute
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Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source