Results 81 to 90 of about 5,414,012 (318)
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
ToxicsVarious geostatistical models have been used in epidemiological research to evaluate ambient air pollutant exposures at a fine spatial scale. Few studies have investigated the performance of different exposure models on population-weighted exposure ...
Yinghan Wu +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
The effects on topic familiarity on online search behaviour and use of relevance criteria
, 2006 This paper presents an experimental study on the effect of topic familiarity on the assessment behaviour of online searchers. In particular we investigate the effect of topic familiarity on the resources and relevance criteria used by searchers.
Wen, Lei +8 more
core +1 more source
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
AtmosphereIn early 2020, China experienced a mass outbreak of a novel coronavirus disease (COVID-19). With an aim to evaluate the impact of emission variations on toxic element species in PM2.5 and the health risks associated with inhalation exposure during COVID ...
Mingsheng Zhao +5 more
doaj +1 more source
A Framework for Ecotoxicity Testing in the 21st Century: Ecotox21
Applied Sciences, 2019 To reduce the considerable investments of toxicity testing and protecting animal welfare, a new toxicity testing strategy based on response pathways of human cell lines has been proposed in the United States to evaluate the chemical exposure risks to ...
Zhen-guang Yan +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Phytoplankton and Eutrophication Degree Assessment of Baiyangdian Lake Wetland, China
The Scientific World Journal, 2013 Eight typical sampling sites were chosen to investigate the phytoplankton community structure and to assess the eutrophication degree of Baiyangdian Lake in 2009.
Xing Wang +5 more
doaj +1 more source