Results 71 to 80 of about 2,262,136 (302)

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

VECTOR-SPACE APPROACH TO EVALUATION OF THE EFFICIENCY OF USE OF RADIOELECTRONIC CONTROLS

Сучасні інформаційні системи, 2019
The intensive development of information and control technologies, as well as their integration into a single information space, leads to an increase in the role of such technologies in the processes of control of troops (forces) and weapons, including ...
Andrii Shyshatskyi, Yurii Zhuravskyi, Alexey Kuvshinov, Taras Hurskyi, Roman Vozniak, Rostislav Pikul, Olga Pikul   +6 more
doaj   +1 more source

Spin entanglement, decoherence and Bohm's EPR paradox [PDF]

, 2015
We obtain criteria for entanglement and the EPR paradox for spin-entangled particles and analyse the effects of decoherence caused by absorption and state purity errors.
Bachor, Hans, Cavalcanti, E G, Drummond, Peter David, Reid, M D   +3 more
core   +1 more source

Efficient Diversification According to Stochastic Dominance Criteria [PDF]

Management Science, 2004
This paper develops the first operational tests of portfolio efficiency based on the general stochastic dominance (SD) criteria that account for an infinite set of diversification strategies. The main insight is to preserve the cross-sectional dependence of asset returns when forming portfolios by reexpressing the SD criteria in T-dimensional ...
openaire   +2 more sources

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

AN EVALUATION OF EXPECTED VALUE AND EXPECTED VALUE-VARIANCE CRITERIA IN ACHIEVING RISK EFFICIENCY IN CROP SELECTION [PDF]

This article evaluates the performance of expected value and expected value-variance criteria in achieving risk efficiency in crop selection. Results indicate that the expected returns criterion achieves risk efficiency in many situations because of ...
Reid, Donald W., Tew, Bernard V.
core   +1 more source

Effects of conventional and organic land use types on water protection criteria in Germany [PDF]

, 2009
The mean values and ranges of several water protection criteria were calculated for arable land, grassland and forests in Germany on the basis of research work and the literature.
Kolbe, Hartmut
core  

Computer Graphics Efficiency Criteria

Journal of Flm Arts and Film Studies, 2013
Computer graphics in modern cinema forms a unique phenomenon akin to the star system becoming the “lure” for mass audience. The article pinpoints the problems of personnel management under the film industry’s adoption of digital technologies, particularly, in creating special effects.
openaire   +2 more sources

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

CRITERIA OF ASSESSMENT OF HIGH SPINAL ANESTHESIA EFFICIENCY IN UPPER ABDOMEN SURGERIES

Acta Biomedica Scientifica, 2017
In recent years, the frequency of application of regional anesthesia methods, and especially in economically developed countries, has progressively increased.
A. B. Yakushevskiy, A. N. Plekhanov, A. V. Zharnikov   +2 more
doaj   +1 more source