Results 41 to 50 of about 5,260,453 (314)
ABSTRACT Objective To evaluate selumetinib exposure using therapeutic drug monitoring (TDM) in pediatric patients with neurofibromatosis type 1 (NF1) and plexiform neurofibromas (PN), assess interpatient pharmacokinetic variability, and explore the relationship between drug exposure, clinical response, and adverse effects.
Janka Kovács +8 more
wiley +1 more source
Critical care utilization in Canada increased from 17 ICU patient days per thousand population in 1969 to 42 ICU patient days per thousand population in 1986) This represented approximately 8% of 1986 total inpatient costs. In the same year, intensive care utilization in the United States was 108 patient days per thousand population, accounting for 20%
openaire +2 more sources
Moral Distress in Critical Care Nursing: The State of the Science [PDF]
Background: Moral distress is a complex phenomenon frequently experienced by critical care nurses. Ethical conflicts in this practice area are related to technological advancement, high intensity work environments, and end-of-life decisions.
Epstein EG +10 more
core +2 more sources
ABSTRACT Objective To evaluate the diagnostic yield and utility of universal paired tumor–normal multigene panel sequencing in newly diagnosed pediatric solid and central nervous system (CNS) tumor patients and to compare the detection of germline pathogenic/likely pathogenic variants (PV/LPVs) against established clinical referral criteria for cancer ...
Natalie Waligorski +9 more
wiley +1 more source
Objective The overall objective of our research is to determine in children with septic shock whether the use of a fluid-sparing strategy results in improved clinical outcomes without an increased risk of adverse events compared to usual care.
Melissa J. Parker +5 more
doaj +1 more source
Child care subsidies critical for low-income families amid rising child care expenses [PDF]
The high cost of child care is a barrier to employment among low-income families with young children. Child care subsidies are designed to support both parental employment and child development by lowering the cost of child care and making high-quality ...
Adams, Nicholas, Smith, Kristin
core +1 more source
Increasing the Capacity of Primary Care Through Enabling Technology. [PDF]
Primary care is the foundation of effective and high-quality health care. The role of primary care clinicians has expanded to encompass coordination of care across multiple providers and management of more patients with complex conditions.
Nesbitt, Thomas S, Young, Heather M
core +1 more source
ABSTRACT Purpose Although not always achieved, complete chemotherapy‐induced nausea and vomiting (CINV) control is the conventional goal of CINV prophylaxis. In this two‐center, mixed‐methods study, we sought to understand the preferences of adolescent patients and family caregivers for CINV control endpoints.
Haley Newman +8 more
wiley +1 more source
Research priorities for data collection and management within global acute and emergency care systems. [PDF]
Barriers to global emergency care development include a critical lack of data in several areas, including limited documentation of the acute disease burden, lack of agreement on essential components of acute care systems, and a lack of consensus on key ...
Bisanzo, Mark +7 more
core +2 more sources
Prehospital critical care is associated with increased survival in adult trauma patients in Scotland [PDF]
Background Scotland has three prehospital critical care teams (PHCCTs) providing enhanced care support to a usually paramedic-delivered ambulance service.
Carr, David +7 more
core +3 more sources

