Results 41 to 50 of about 5,260,453 (314)

Personalized Selumetinib Dosing in Pediatric Neurofibromatosis Type 1: Insights From a Pilot Therapeutic Drug Monitoring Study

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate selumetinib exposure using therapeutic drug monitoring (TDM) in pediatric patients with neurofibromatosis type 1 (NF1) and plexiform neurofibromas (PN), assess interpatient pharmacokinetic variability, and explore the relationship between drug exposure, clinical response, and adverse effects.
Janka Kovács   +8 more
wiley   +1 more source

Critical care audit [PDF]

open access: yesCanadian Journal of Anaesthesia, 1992
Critical care utilization in Canada increased from 17 ICU patient days per thousand population in 1969 to 42 ICU patient days per thousand population in 1986) This represented approximately 8% of 1986 total inpatient costs. In the same year, intensive care utilization in the United States was 108 patient days per thousand population, accounting for 20%
openaire   +2 more sources

Moral Distress in Critical Care Nursing: The State of the Science [PDF]

open access: yes, 2018
Background: Moral distress is a complex phenomenon frequently experienced by critical care nurses. Ethical conflicts in this practice area are related to technological advancement, high intensity work environments, and end-of-life decisions.
Epstein EG   +10 more
core   +2 more sources

Evaluating the Utility of Paired Tumor and Germline Targeted DNA Sequencing for Pediatric Oncology Patients: A Single Institution Report

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate the diagnostic yield and utility of universal paired tumor–normal multigene panel sequencing in newly diagnosed pediatric solid and central nervous system (CNS) tumor patients and to compare the detection of germline pathogenic/likely pathogenic variants (PV/LPVs) against established clinical referral criteria for cancer ...
Natalie Waligorski   +9 more
wiley   +1 more source

The SQUEEZE pilot trial: a trial to determine whether septic shock reversal is quicker in pediatric patients randomized to an early goal directed fluid-sparing strategy vs. usual care

open access: yesPilot and Feasibility Studies
Objective The overall objective of our research is to determine in children with septic shock whether the use of a fluid-sparing strategy results in improved clinical outcomes without an increased risk of adverse events compared to usual care.
Melissa J. Parker   +5 more
doaj   +1 more source

Child care subsidies critical for low-income families amid rising child care expenses [PDF]

open access: yes, 2013
The high cost of child care is a barrier to employment among low-income families with young children. Child care subsidies are designed to support both parental employment and child development by lowering the cost of child care and making high-quality ...
Adams, Nicholas, Smith, Kristin
core   +1 more source

Increasing the Capacity of Primary Care Through Enabling Technology. [PDF]

open access: yes, 2017
Primary care is the foundation of effective and high-quality health care. The role of primary care clinicians has expanded to encompass coordination of care across multiple providers and management of more patients with complex conditions.
Nesbitt, Thomas S, Young, Heather M
core   +1 more source

Preferences of Pediatric Patients and Their Caregivers for Chemotherapy‐Induced Nausea and Vomiting Control Endpoints: A Mixed Methods Study

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Purpose Although not always achieved, complete chemotherapy‐induced nausea and vomiting (CINV) control is the conventional goal of CINV prophylaxis. In this two‐center, mixed‐methods study, we sought to understand the preferences of adolescent patients and family caregivers for CINV control endpoints.
Haley Newman   +8 more
wiley   +1 more source

Research priorities for data collection and management within global acute and emergency care systems. [PDF]

open access: yes, 2013
Barriers to global emergency care development include a critical lack of data in several areas, including limited documentation of the acute disease burden, lack of agreement on essential components of acute care systems, and a lack of consensus on key ...
Bisanzo, Mark   +7 more
core   +2 more sources

Prehospital critical care is associated with increased survival in adult trauma patients in Scotland [PDF]

open access: yes, 2020
Background Scotland has three prehospital critical care teams (PHCCTs) providing enhanced care support to a usually paramedic-delivered ambulance service.
Carr, David   +7 more
core   +3 more sources

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