Results 41 to 50 of about 12,324,592 (318)

Emapalumab for Immune Effector Cell‐Associated Hemophagocytic Lymphohistiocytosis‐Like Syndrome Following CD19‐Directed CAR‐T in Two Patients With B‐ALL: Clinical and Biomarker Correlates

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Immune effector cell‐associated hemophagocytic lymphohistiocytosis‐like syndrome (IEC‐HS) is a life‐threatening hyperinflammatory toxicity distinct from cytokine release syndrome (CRS) and neurotoxicity following chimeric antigen receptor T‐cell (CAR‐T) therapy. In a single‐institution retrospective cohort of pediatric and young adult patients
Thomas J. Galletta, Jeremy D. Rubinstein, Christopher E. Dandoy, Ruby Khoury, Angela Faulhaber, Christine L. Phillips, Christa Krupski   +6 more
wiley   +1 more source

Consensus on Hemodynamic Management in Adult Veno-Arterial Extracorporeal Membrane Oxygenation (2026 Edition)

Xiehe Yixue Zazhi
Despite significant advances in the field of critical care medicine over the past three decades, veno-arterial extracorporeal membrane oxygenation (V-A ECMO) remains the primary temporary mechanical circulatory support modality for patients with acute ...
CHENG Wei, CAI Shuhan, ZHU Ying, CEN Zhongran, ZHAO Hua, CHEN Huan, CHAO Yangong, WANG Xiaoting, DING Xin, China Critical Care Ultrasound Study Group, Critical Care Hemodynamic Therapy Collaboration Group, Critical Care Medicine Branch of China International Exchange and Promotive Association for Medical and Health Care   +11 more
doaj   +1 more source

Nurses’ perceptions and demands regarding COVID-19 care delivery in critical care units and hospital emergency services

Intensive & Critical Care Nursing, 2020
Highlights • Critical care nurses have had to perform tasks for which they have not received proper training.• Nurses have had to manage the fear of becoming infected and spreading it to their families.• Moral suffering and emotional exhaustion are major
M. T. González-Gil, C. González-Blázquez, A. Parro-Moreno, Azucena Pedraz-Marcos, A. Palmar-Santos, L. Otero-García, M. Navarta-Sánchez, M. T. Alcolea-Cosín, M. T. Argüello-López, C. Canalejas-Pérez, María Elena Carrillo-Camacho, M. Casillas-Santana, María Luisa Díaz-Martínez, Asunción García-González, Eva García-Perea, M. Martínez-Marcos, M. L. Martínez-Martín, María del Pilar Palazuelos-Puerta, Carmen Sellán-Soto, C. Oter-Quintana   +19 more
semanticscholar   +1 more source

The Role of Hematopoietic Cell Transplantation in Ataxia‐Telangiectasia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Ataxia‐telangiectasia (A‐T) is a DNA repair disorder characterized by neurodegeneration, immunodeficiency, and cancer predisposition. Hematopoietic cell transplantation (HCT) is an established therapy in related disorders such as Fanconi anemia (FA) and Nijmegen breakage syndrome (NBS), but its role in A‐T is unclear.
Laila Alkhouli, Seth Rotz, Masatoshi Takagi, Richa Sharma   +3 more
wiley   +1 more source

Small Extracellular Vesicles Secreted by iPSC-Derived MSCs Ameliorate Pulmonary Inflammation and Lung Injury Induced by Sepsis through Delivery of miR-125b-5p

Journal of Immunology Research, 2023
Background. Sepsis-induced acute lung injury is a common critical illness in intensive care units with no effective treatment is currently available.
Wei Peng, Yun Yang, Jiaquan Chen, Zeyao Xu, Yuanlei Lou, Qi Li, Ning Zhao, Kejian Qian, Fen Liu   +8 more
doaj   +1 more source

Critical care audit [PDF]

Canadian Journal of Anaesthesia, 1992
Critical care utilization in Canada increased from 17 ICU patient days per thousand population in 1969 to 42 ICU patient days per thousand population in 1986) This represented approximately 8% of 1986 total inpatient costs. In the same year, intensive care utilization in the United States was 108 patient days per thousand population, accounting for 20%
openaire   +2 more sources

The effect of COVID-19 pandemic on the mental health of Canadian critical care nurses providing patient care during the early phase pandemic: A mixed method study

Intensive & Critical Care Nursing, 2020
Background Healthcare workers have historically experienced symptoms of post-traumatic stress disorder, depression and anxiety with previous infectious outbreaks. It is unknown if critical care nurses have similar experiences.
Sarah Crowea, Sarah Crowea, A. Howard, Brandi Vanderspank-Wright, Brandi Vanderspank-Wright, Paula Gillis, Fiona Mcleod, Caroline Penner, Greg Haljan   +8 more
semanticscholar   +1 more source

Increased Risk of Sarcomas in Children With Congenital Anomalies: Findings From the Genetic Overlap Between Anomalies and Cancer in Kids (GOBACK) Registry Linkage Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Pediatric sarcomas are a heterogeneous group of tumors that contribute disproportionately to cancer mortality in children. Although congenital anomalies are among the strongest known risk factors for childhood cancer, the risk of specific sarcoma subtypes among affected individuals has not yet been thoroughly evaluated. Procedure We
Russ Wolters, Ji Yun Tark, Tiffany M. Chambers, Tania A. Desrosiers, Michael E. Scheurer, Charles Shumate, Wendy N. Nembhard, Mahsa M. Yazdy, Eirini Nestoridi, Amanda E. Janitz, Jean Paul Tanner, Russell S. Kirby, Jason L. Salemi, Yao Yu, Chad D. Huff, Sharon E. Plon, Philip J. Lupo, Jeremy M. Schraw   +17 more
wiley   +1 more source

Data-driven spatial–temporal framework for exploring the heterogeneity and temporality of sepsis

Chinese Medical Journal
. Sepsis remains a leading cause morbidity and mortality worldwide; effective targeted therapies remain elusive due to its inherent heterogeneity and dynamic temporal evolution.
Yehan Qiu, Xiang Zhou, On behalf of China Critical Care Clinical Trials Group (CCCCTG) and China National Critical Care Quality Control Center Group (China-NCCQC group), Xuehong Zhang, Jing Ni   +4 more
doaj   +1 more source

Biomarkers in critical care nutrition

Critical Care, 2020
The goal of nutrition support is to provide the substrates required to match the bioenergetic needs of the patient and promote the net synthesis of macromolecules required for the preservation of lean mass, organ function, and immunity.
C. Stoppe, Sebastian Wendt, N. Mehta, C. Compher, J. Preiser, D. Heyland, A. Kristof   +6 more
semanticscholar   +1 more source