Results 101 to 110 of about 895,229 (373)

2378 Addressing challenges from missing data in a global quality improvement study

Journal of Clinical and Translational Science, 2018
OBJECTIVES/SPECIFIC AIMS: Missing data is a common problem in research studies that may lead to inconclusive or inaccurate results. It may even lead to harm secondary to wrong research conclusions.
Amelia Barwise, Lisha Yi, Jun Guo, Ognjen Gajic, Moldovan Sabov, Yue Dong, Rahul Kashyap   +6 more
doaj   +1 more source

Decrypting cancer's spatial code: from single cells to tissue niches

Molecular Oncology, EarlyView.
Spatial transcriptomics maps gene activity across tissues, offering powerful insights into how cancer cells are organised, switch states and interact with their surroundings. This review outlines emerging computational, artificial intelligence (AI) and geospatial approaches to define cell states, uncover tumour niches and integrate spatial data with ...
Cenk Celik, Shi Pan, Eloise Withnell, Hou Wang Lam, Maria Secrier   +4 more
wiley   +1 more source

Surviving physiological stress: Can insights into human adaptation to austere environments be applied to the critical care unit? [PDF]

, 2016
The harshest environment that many people will ever face is the critical care unit, where pathology can stress homeostatic mechanisms beyond their limits, leading to multiple organ failure and death.
Martin, D, McKenna, H
core   +1 more source

Year in review in Intensive Care Medicine 2011. II. Cardiovascular, infections, pneumonia and sepsis, critical care organization and outcome, education, ultrasonography, metabolism and coagulation

Intensive Care Medicine, 2012
Year in review in Intensive Care Medicine 2011. II. : Cardiovascular, infections, pneumonia and sepsis, critical care organization and outcome, education, ultrasonography, metabolism and ...
Massimo Antonelli, M. Bonten, J. Chastre, G. Citerio, G. Conti, Randall Curtis, D. D. Backer, G. Hedenstierna, M. Joannidis, D. Macrae, J. Mancebo, S. Maggiore, A. Mebazaa, J. Preiser, P. Rocco, J. Timsit, J. Wernerman, Haibo Zhang   +17 more
semanticscholar   +1 more source

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

Clinical profile and outcome in a paediatric intensive care unit in Pakistan [PDF]

, 2009
Paediatric critical care medicine is a relatively new subspecialty in Pakistan. The clinical profile and outcomes of children admitted in the PICU (paediatric intensive care unit) were retrospectively reviewed from January to December 2007.
Bano, Surraiya, Haque, Anwarul
core   +1 more source

Machine learning in critical care: state-of-the-art and a sepsis case study [PDF]

, 2018
Background: Like other scientific fields, such as cosmology, high-energy physics, or even the life sciences, medicine and healthcare face the challenge of an extremely quick transformation into data-driven sciences.
Morales, Carlos, Ribas Ripoll, Vicent, Ruiz Rodriguez, Juan Carlos, Ruiz Sanmartín, Adolf, Vellido Alcacena, Alfredo   +4 more
core   +4 more sources

Gastrointestinal dysfunction in the critically ill: a systematic scoping review and research agenda proposed by the Section of Metabolism, Endocrinology and Nutrition of the European Society of Intensive Care Medicine

Critical Care, 2020
Background Gastrointestinal (GI) dysfunction is frequent in the critically ill but can be overlooked as a result of the lack of standardization of the diagnostic and therapeutic approaches.
A. Reintam Blaser, J. Preiser, Sonja Fruhwald, Alexander Wilmer, J. Wernerman, C. Benstoem, M. Casaer, Joel Starkopf, A. V. van Zanten, O. Rooyackers, Stephan M. Jakob, C. Loudet, D.E. Bear, G. Elke, M. Kott, I. Lautenschläger, Jörn Schäper, J. Gunst, Christian Stoppe, Leda Nobile, Valentin Fuhrmann, Mette M. Berger, H. O. Oudemans-van Straaten, Yaseen M. Arabi, A. Deane, Annika Jean-Charles Sonja Alexander Jan Carina Michael P. Reintam Blaser Preiser Fruhwald Wilmer Wernerman B, A. Reintam Blaser, J. Preiser, Sonja Fruhwald, Alexander Wilmer, J. Wernerman, C. Benstoem, M. Casaer, Joel Starkopf, A. V. van Zanten, O. Rooyackers, Stephan M. Jakob, C. Loudet, D.E. Bear, G. Elke, M. Kott, I. Lautenschläger, Jörn Schäper, J. Gunst, Christian Stoppe, Leda Nobile, Valentin Fuhrmann, Mette M. Berger, H. O. Oudemans-van Straaten, Yaseen M. Arabi, Adam Dean, K. Amrein, G. Besch, Brenno Belazi Nery de Souza Campos, E. de Waele, V. Fraipont, Teodoro Grau, Kursat Gundogan, C. Heidegger, M. Hiesmayr, C. Ichai, M. Juan-Díaz, Kurt Købke-Jacobsen, V. Koutsoukou, M. Laube, J. C. Montejo González, Z. Puthucheary, A. Rousseau, P. Singer, S. Stapel, H. Tekguc, Carlos Torruco-Sotelo   +71 more
semanticscholar   +1 more source

A bioinformatics screen identifies TCF19 as an aggressiveness‐sustaining gene in prostate cancer

Molecular Oncology, EarlyView.
Gene expression meta‐analysis in multiple prostate cancer patient cohorts identifies Transcription factor 19 (TCF19) as an aggressiveness‐sustaining gene with prognostic potential. TCF19 is a gene repressed by androgen signaling that sustains core cancer‐related processes such as vascular permeability or tumor growth and metastasis.
Amaia Ercilla, Jana R. Crespo, Saioa Garcia‐Longarte, Marta Fidalgo, Sara del Palacio, Natalia Martin‐Martin, Onintza Carlevaris, Ianire Astobiza, Sonia Fernández‐Ruiz, Marc Guiu, Laura Bárcena, Isabel Mendizabal, Ana M. Aransay, Mariona Graupera, Roger R. Gomis, Arkaitz Carracedo   +15 more
wiley   +1 more source

Spotlight on bereavement care in the ICU [PDF]

, 2018
Intensive care units (ICUs) are dedicated to supporting and saving lives; yet, despite medical advances, a significant number of critically ill patients die in this setting. International mortality rates in adult ICUs in North America (Canadian Institute
Trapani, Dr Josef, Walker, Wendy
core   +1 more source