Results 111 to 120 of about 357,533 (318)

Experience of a vascular ultrasound-guided program: from the ICU to the hospital

The Ultrasound Journal
Background The use of peripherally inserted central venous catheters (PICCs) has increased worldwide in the last decade. However, PICCs are associated to catheter-related thrombosis (CRT) and central line-associated bloodstream infections (CLABSIs).
Miguel Angel Oviedo-Torres, Andrés Felipe Yepes-Velasco, Jeimy Lorena Moreno-Araque, David Rene Rodríguez-Lima, Andrés Felipe Mora-Salamanca   +4 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Year in review in Intensive Care Medicine 2012: I. Neurology and neurointensive care, epidemiology and nephrology, biomarkers and inflammation, nutrition, experimentals [PDF]

, 2012
Non
Rocco, P, Jan Wernerman, Preiser, Jean-Charles, Mancebo, J, Timsit, JF, Salvatore M. Maggiore, Mancebo, Jordi, Maggiore, Salvatore M, Mebazaa, A, Jordi Mancebo, Curtis, JR, Bonten, M, Marc Bonten, Conti, G, Macrae, D, Antonelli, M, Curtis, Randall J.R., Maggiore, Salvatore Maurizio, Rocco, Patricia, Chastre, J, Maggiore, Salvatore M., Preiser, JC, Giorgio Conti, Chastre, Jean, Giuseppe Citerio, Citerio, Giuseppe, Goran Hedenstierna, Mebazaa, Alexandre, Maggiore, SM, Antonelli, Massimo, Joannidis, Michael, Timsit, Jean François, Massimo Antonelli, Jean Chastre, Wernerman, J, Maurizio Cecconi, J. Randall Curtis, Hedenstierna, Goran, Timsit, Jean-François, Joannidis, M, Haibo Zhang, Citerio, G, Jean-François Timsit, Jean-Charles Preiser, MacRae, Duncan, Alexandre Mebazaa, Michael Joannidis, Preiser, Jean Charles, Hedenstierna, Göran,, Conti, Giorgio, Cecconi, M, Hedenstierna, G, Wernerman, Jan, Bonten, Marc, Cecconi, Maurizio, Patricia Rocco, Curtis, J.Randall, Universitat Autònoma de Barcelona, Zhang, H, Zhang, Haibo, Duncan Macrae, Curtis, J Randall   +61 more
core   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Critical care use during the course of serious illness. [PDF]

, 2004
Despite its expense and importance, it is unknown how common critical care use is. We describe longitudinal patterns of critical care use among a nationally representative cohort of elderly patients monitored from the onset of common serious illnesses. A
Theodore J. Iwashyna, Iwashyna, Theodore J.   +1 more
core  

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Application of Sepsis-3 Criteria to Korean Patients with Critical Illnesses [PDF]

, 2019
Background: The 2016 Society of Critical Care Medicine (SCCM)/European Society of Intensive Care Medicine (ESICM) task force for Sepsis-3 devised new definitions for sepsis, sepsis with organ dysfunction and septic shock.
나성원
core   +1 more source

Modified Thoracoabdominal Nerve Block Through the Perichondrial Approach versus Thoracic Epidural Analgesia for Postoperative Analgesia in Robot-Assisted Colorectal Surgery: A Retrospective Cohort Study

Local and Regional Anesthesia
Tatsuya Yamamoto, Yukiko Yoshida, Yoko Ochiai, Masao Hayashi, Katsuhisa Kawaguchi, Masaaki Michida, Mizuho Matsushima, Hiroshi Katayama, Ichiro OhashiDepartment of Anesthesiology and Critical Care Medicine, Kawasaki Medical School General Medical Center,
Yamamoto T, Yoshida Y, Ochiai Y, Hayashi M, Kawaguchi K, Michida M, Matsushima M, Katayama H, Ohashi I   +8 more
doaj  

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source