Results 111 to 120 of about 804,475 (313)

Effect of Trans-Nasal Evaporative Intra-arrest Cooling on Functional Neurologic Outcome in Out-of-Hospital Cardiac Arrest : The PRINCESS Randomized Clinical Trial [PDF]

, 2019
© 2019 American Medical Association. All rights reserved.Importance: Therapeutic hypothermia may increase survival with good neurologic outcome after cardiac arrest.
Abella, Abou-Chebl, Adeline Higuet, Anatolij Truhlar, Bernard, Bernard, Busch, Callaway, Caroline Busche, Castrén, Che, David Konrad, Debaty, Didier Desruelles, Emelie Dillenbeck, Fabio Silvio Taccone, Fernando Rosell Ortiz, Francisco Carmona Jiménes, Froehler, Hans-Jörg Busch, Hypothermia after Cardiac Arrest Study Group, Jacob Hollenberg, Jacques Creteur, Jean-Louis Vincent, Jennett, Jerome Cuny, Johan Peterson, Julia Williams, Kim, Leif Svensson, Martin Jonsson, Mattias Ringh, Nick Vermeersch, Nielsen, Nolan, Nolan, Nordberg, Patrick Goldstein, Per Nordberg, Perkins, Scolletta, Sune Forsberg, Yu, Zhang   +43 more
core   +3 more sources

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Effect of external PEEP in patients under controlled mechanical ventilation with an auto-PEEP of 5 cmH2O or higher. [PDF]

, 2016
In some patients with auto-positive end-expiratory pressure (auto-PEEP), application of PEEP lower than auto-PEEP maintains a constant total PEEP, therefore reducing the inspiratory threshold load without detrimental cardiovascular or respiratory effects.
Amodeo, Guido, Bernardini, Achille, Berruto, Francesco, Filippini, Matteo, Fiorillo, Marialinda, Grazioli, Michele, Lucangelo, U., Marsilia, Paolo F., Minelli, Cosetta, Natalini, Giuseppe, Pennestr\uec, Vincenzo, Peratoner, Alberto, Rosano, Antonio, Testa, Marco, Tinnirello, Andrea, Tuzzo, Daniele, Ventilab, Group   +16 more
core   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Diaphragmatic Hernia-Induced Severe Acute Pancreatitis: A Rare Cause of Abdominal Pain and Distributive Shock

Journal of Investigative Medicine High Impact Case Reports
Diaphragmatic hernia (DH) is a condition characterized by the passage of abdominal content into the thorax. The acute symptoms associated with this entity are uncommon, pancreatic herniation being very rare.
Julián Orlando Casallas-Barrera MSc, Alejandro Concha-Mejía MD, Claudia Marcela Poveda-Henao MSc, Carol Aponte-Carrascal MD, Omar Julián Chavarro-Alfonso MD, Nicolás Alejandro Cuevas Jiménez RN   +5 more
doaj   +1 more source

Comparação do perfil dos pacientes que internaram na UTI do HU/UFSC e foram a óbito com o daqueles que receberam alta hospitalar. [PDF]

, 2005
Trabalho de Conclusão de Curso - Universidade Federal de Santa Catarina. Curso de Medicina.
Cardoso, Hugo Alfredo Koerich Vieira
core  

Critically ill patients with cancer: chances and limitations of intensive care medicine—a narrative review

ESMO Open, 2016
This narrative review deals with the challenge of defining adequate therapy goals and intensive care unit (ICU) admission criteria for critically ill patients with cancer. Several specific complications of critically ill patients with cancer require close collaborations of intensive care and cancer specialists.
Schellongowski, Peter, Sperr, Wolfgang R, Wohlfarth, Philipp, Knoebl, Paul, Rabitsch, Werner, Watzke, Herbert H, Staudinger, Thomas   +6 more
openaire   +2 more sources

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source