Results 111 to 120 of about 2,363,196 (290)

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Influence of Constant Current Accelerated Corrosion on the Bond Properties of Reinforced Concrete

International Journal of Electrochemical Science, 2019
Reinforcement corrosion is one of the most serious durability problems faced by reinforced concrete (RC) structures. In the laboratory, current accelerated corrosion method is widely used to corrode RC structures. In order to reduce the experimental time,
Yang Sun, Guofu Qiao
doaj   +1 more source

Critical state solution and AC loss computation of polygonally arranged thin superconducting tapes

, 2013
The current density and field distributions in polygonally arranged thin superconducting tapes carrying AC current are derived under the assumption of the critical state model.
Brambilla, Roberto, Grilli, Francesco, Martini, Luciano   +2 more
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Case Studies on Time-Dependent Ginzburg-Landau Simulations for Superconducting Applications

Electromagnetic Science
The macroscopic electromagnetic properties of type-II superconductors are mainly influenced by the behavior of microscopic superconducting flux quantum units.
Cun Xue, Qing-Yu Wang, Han-Xi Ren, An He, Alejandro V. Silhanek   +4 more
doaj   +1 more source

Current-induced domain wall motion in a nanowire with perpendicular magnetic anisotropy

, 2008
We study theoretically the current-induced magnetic domain wall motion in a metallic nanowire with perpendicular magnetic anisotropy. The anisotropy can reduce the critical current density of the domain wall motion. We explain the reduction mechanism and
Jung, Soon-Wook, Kim, Woojin, Lee, Hyun-Woo, Lee, Kyung-Jin, Lee, Taek-Dong   +4 more
core   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Reemergence of superconductivity by 4d transition-metal Pd doping in over-doped 112-type iron pnictide superconductors Ca0.755La0.245FeAs2

New Journal of Physics, 2019
In 112-type iron-based superconductors (IBSs), rare earth (e.g. La) doping enhanced antiferromagnetic (AFM) order and 3 d transition-metal (e.g. Co, Ni) doping induced reemergence of superconductivity (SC) in the over-doped regime (non-SC) are of ...
Xiangzhuo Xing, Zhanfeng Li, Ivan Veshchunov, Xiaolei Yi, Yan Meng, Meng Li, Bencheng Lin, Tsuyoshi Tamegai, Zhixiang Shi   +8 more
doaj   +1 more source

Improvement of superconducting parameters of Bi1.6Pb0.4Sr 2Ca 2Cu 3O10+ δ added with Au nanoparticles

Iraqi Journal of Physics, 2018
Samples of Bi1.6Pb0.4Sr2Ca2Cu3O10+δ superconductor were prepared by solid-state reaction method to study the effects of gold nanoparticles addition to the superconducting system, Nano-Au was introduced by small weight percentages (0.25, 0.50, 0.75, 1.0,
Amal K. Jassim
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source