Results 91 to 100 of about 39,350,562 (254)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

New Perspectives in Critical Data Studies The Ambivalences of Data Power

New Perspectives in Critical Data Studies -- Contents -- List of Figures -- List of Tables -- List of Images -- Notes on Contributors -- New Perspectives in Critical Data Studies: The Ambivalences of Data Power-An Introduction -- Introduction -- Critical
Jarke, Juliane., Hepp, Andreas., Kramp, Leif.   +2 more
core  

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Climate Change and Critical Agrarian Studies

Climate change is perhaps the greatest threat to humanity today and plays out as a cruel engine of myriad forms of injustice, violence and destruction.

core   +1 more source

Beyond Mobility Flows: A Network Perspective on Academic Exchange and National Innovation Performance

Information
International academic exchange is widely regarded as an important mechanism of knowledge transfer and international collaboration, yet relatively little is known about how countries’ structural positions within academic mobility networks relate to ...
Darija Korkut, Zoran Levnajić, Robert Kopal   +2 more
doaj   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Skeptical to AI Like a Data Scientist. Results from a Polish Sociological Study of the So-Called Artificial Intelligence Developers Community and Suggestions for Academic Teachers

Lubelski Rocznik Pedagogiczny
Introduction: Generative artificial intelligence (AI) systems have sparked another wave of enthusiasm toward AI. This article presents AI from a data science (DS) perspective. DS is involved in developing and implementing AI.
Remigiusz Żulicki
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Missing Data as Political Force

DIID
In today’s society, data shapes how states and corporations treat people. It is closely connected to questions of economic, cultural and political representation and equality.
Max Frischknecht
doaj   +1 more source