Results 101 to 110 of about 39,350,562 (254)

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Dreaming Like a Market: The Hidden Script of Financial Inclusion in China’s P2P Lending Platforms

, 2020
In the past ten years, Chinese people of different social strata swarmed into the Peer to Peer (P2P) lending industry as lenders and borrowers. Meanwhile, stories circulated across the media about desperate investors who lost their life’s savings on ...
RAO, Y
core  

Handbook of Critical Policy Studies

, 2017
Critical policy studies, as illustrated in this Handbook, challenges the conventional approaches public policy inquiry. But it offers important innovations as well, in particular its focus on discursive politics, policy argumentation and deliberation ...

core   +2 more sources

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

The domestic violence gap in social vulnerability assessments

Progress in Disaster Science
Despite strong evidence linking natural hazards to increased domestic violence (DV), social vulnerability (SV) assessments, the primary means of accounting for social factors in U.S. disaster risk, rarely consider DV.
Shelley Hoover
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Episode 63: Critical Animal Studies with Carol Gigliotti

, 2018
In this episode of Knowing Animals I speak to artist, advocate and independent scholar Carol Gigliotti. Today we will focus on Carol’s book chapter ‘The Struggle for Compassion and Justice through Critical Animal Studies’, which was published in 2015 as ...
O'Sullivan, Siobhan, Gigliotti, Carol
core   +1 more source

Du mouvement des cartes SIM aux mobilités touristiques : une analyse de Flux Vision Tourisme comme procédure de quantification

Bulletin de l’Association de Géographes Français
Flux Vision is a commercial product of the mobile network provider Orange, which quantifies the presence and movement of people in a given area based on the signals recorded by the network of antennas of the company.
Valérian Geffroy
doaj   +1 more source