Results 111 to 120 of about 39,350,562 (254)

Critique and Contribute: A Practice-Based Framework for Improving Critical Data Studies and Data Science. [PDF]

Big Data, 2017
Neff G, Tanweer A, Fiore-Gartland B, Osburn L.   +3 more
europepmc   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

The ghost in the system: Critical management studies in Turkey

, 2016
Critical Management Studies (CMS) did not find a place and could not establish itself in Turkish business schools. This is not a new claim; it has been argued by extant research.
Gençer, M., Oba, B.
core   +1 more source

Indigenous Governance of Data Held by Organisations: How to Operationalise Indigenous Data Sovereignty Principles in Australia

Data Science Journal
Indigenous Data Sovereignty has emerged in response to poor data practices concerning Indigenous Peoples worldwide and offers a way of returning control of data ecosystems to Indigenous Peoples.
Cassandra Sedran-Price, Riley Taitingfong, Rose Barrowcliffe, Jacob Prehn, Maggie Walter, Gawaian Bodkin-Andrews, Raymond Lovett   +6 more
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

No emancipatory alternative, no critical security studies

, 2013
We offer a provocation – that we should stop appending ‘Critical’ to ‘Security Studies’. Critical security as an academically and politically contested terrain is no longer productive of emancipatory alternatives. In making this claim, we seek to reflect
Hynek, N., Chandler, D.C.
core   +1 more source

Decentering Technology in the Datafied Workplace: Data (In)Justice and Workers’ Experiences of Algorithmic Management in Call Centers in the United Kingdom and Greece

International Journal of Communication
This article makes a key contribution to debates on algorithmic management by bringing together insights from labor process analysis and critical data studies to examine how workers experience and understand injustices related to the introduction of data-
Lina Dencik, Jess Brand, Philippa Metcalfe   +2 more
doaj   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source