Results 201 to 210 of about 28,069,313 (292)

Bundibugyo ebolavirus emergence in eastern Democratic Republic of Congo: The critical role of risk communication and community engagement in strengthening health security in fragile and conflict-affected settings. [PDF]

J Virus Erad
Kihanduka E, Tague C, Nadarajah S, Rugendabanga E, Akilimali A, Muyisa B, Mugenyi N, Byakika-Kibwika P.   +7 more
europepmc   +1 more source

MARK4 enhances stress granule formation under oxidative stress and increases tau accumulation

FEBS Open Bio, EarlyView.
MARK4 (red dots) localizes to stress granules (orange dots) and promotes their formation under oxidative stress by modulating TIA1 (blue dots). MARK4 and TIA1 synergistically increase tau (purple) accumulation, and the reduction of the TIA1 ortholog suppresses neurodegeneration in a fly model.
Sho Nakajima, Kotone Watanabe, Grigorii Sultanakhmetov, Aoi Fukuchi, Keiya Ito, Sawako Shimizu, Taro Saito, Akiko Asada, Kanae Ando   +8 more
wiley   +1 more source

Robotic Cholecystectomy and Common Bile Duct Exploration: Multidisciplinary Approach in a Complex Case of Choledocholithiasis. [PDF]

J Clin Med
De Palma C, Delvecchio A, Varvara M, D'Errico F, Decembrino F, Di Giovanni G, Inchingolo R, Memeo R, Tedeschi M.   +8 more
europepmc   +1 more source

Evaluating GenAI‐produced feedback on undergraduate bioscience essays against good higher education feedback practice

FEBS Open Bio, EarlyView.
This pilot study investigates the potential of Generative AI to provide formative feedback to students. ChatGPT was prompted to provide feedback on Year 1 Bioscience essays, which were evaluated against established good feedback practices. GenAI‐authored feedback had useful elements, but was limited in scope. GenAI may have potential to provide instant,
Annabel Court, Nigel Francis, Andrew Shore, Stephen Rutherford   +3 more
wiley   +1 more source

Predictors and Mortality Determinants of Non-Thyroidal Illness Syndrome Among Patients in the Medical Intensive Care Unit in Northeastern Tanzania. [PDF]

Clin Med Insights Endocrinol Diabetes
Mattaka NA, Lyaruu IA, Nangawe J, Sadiq AM, Muhali FS, Mkwizu EW, Kilonzo KG, Akrabi HF, Lyamuya FS, Nyakunga GB, Shao ER, Thomas E, Peter SC, Leonard L, Ongujo P, Ntale N, Hamad RS, Mariwa B, Magohe EM, Moshi B, Chamba NG.   +20 more
europepmc   +1 more source

IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo

FEBS Open Bio, EarlyView.
To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley   +1 more source

Outpatient non-operative treatment of uncomplicated acute appendicitis: meta-analysis. [PDF]

BJS Open
Podda M, Pisanu A, Catena F, Ceresoli M.
europepmc   +1 more source

Type I interferons modulate autophagy to shape gemcitabine response in pancreatic cancer cells

FEBS Open Bio, EarlyView.
Type I interferons differentially modulate autophagy and the response of pancreatic cancer cells to gemcitabine. IFNα2b stimulates autophagic flux and protects cells from gemcitabine‐induced cell death, contributing to chemoresistance. In contrast, IFNβ1a inhibits autophagosome formation and enhances gemcitabine‐induced cell death, resulting in ...
Lucy E. Bonilla, Martín M. Ledesma, Santiago A. Behr, Matías A. Pibuel, María L. Palanek, Daniel H. Grasso, Maria N. Garcia, Juan Garona, Silvina L. Lompardía, Elida Álvarez, Daniela L. Papademetrio   +10 more
wiley   +1 more source

The Hotspots and Publication Trends in Central Venous Catheter-Related Bloodstream Infection: A Bibliometric Analysis. [PDF]

Nurs Crit Care
Li J, Li Z, Wang L, Liu X, Zhu J.
europepmc   +1 more source

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

FEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao, Xiaoting Kang, Lulu Meng, Shaoxuan Zhang, Qiujie Li, Jinyu Zhou, Mengyue Xue, Chu Li, Hua Zhu, Pengzhou Hang, Jing Zhao   +10 more
wiley   +1 more source