Results 111 to 120 of about 1,039,545 (289)
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
Institutionalizing an environmental agenda in business [PDF]
, 2003 This paper studies the extent and manner in which an environmental agenda is being institutionalised in two companies in the UK water industry through discursive practices.
Schaefer, Anja
core
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Government Spending In The Context Of The Developing Country Paradigm in Jamaica [PDF]
There has been much discourse in the public media about the quality of and effectiveness of government spending in Jamaica. However to put in context and do a comparative analysis should serve to highlight critical discourse analysis and thinking rather ...
Peter W Jones
core
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Review Essay: Conversation Analysis Versus Other Approaches to Discourse
Forum: Qualitative Social Research, 2006 This review discusses a recent book by Robin WOOFFITT in which conversation analysis (CA) is confronted with some other analytic approaches to "discourse." The author uses the term discourse analysis in a rather specific way, as a label for an analytic ...
Paul Ten Have
doaj
A Critical Discourse Analysis of the Past and Present Conflict for Scottish Independence
, 2015 A study of the language and word patterns used in the past and present conflict over Scottish ...
Fox, Avery N.
core
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
An Interpretation of the Competitive Yardstick Model Using Critical Discourse Analysis [PDF]
Agribusiness,
Hogeland, Julie A.
core +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source