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Contextualism in Normative Political Theory and the Problem of Critical Distance [PDF]

Ethical Theory and Moral Practice, 2019
Political theory is contextualist when factual claims about context are part of the justification of normative political judgments. There are different kinds of contextualism depending on whether context is relevant for the formulation and justification of political principles (methodological contextualism), whether principles themselves are ...
openaire   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Dragging a polymer chain into a nanotube and subsequent release

, 2008
We present a scaling theory and Monte Carlo (MC) simulation results for a flexible polymer chain slowly dragged by one end into a nanotube. We also describe the situation when the completely confined chain is released and gradually leaves the tube.
Aktson M., Cacciuto A., Clausen-Schaumann H., Daoud M., des Cloizeaux J., Ennis J., Grassberger P., Hsu H. P., Hsu H. P., Hsu H.-P., Kasianowicz J. J., Kremer K., Meller A., Meller A., Milchev A., Milchev A., Pincus P., Randel R., Reisner W., Sakaue T., Salman H., Sevick E. M., Sotta P., Steels B. M., Subramanian G., Williams M. C., Yang Y.   +26 more
core   +1 more source

Take AIM and Keep Your Students Engaged

Journal of Open, Flexible and Distance Learning, 2014
This paper outlines the benefits to distance education teachers of formatting a weekly online newsletter in accordance with motivational learning theory.
Catherine Theresa Mary Nash
doaj   +2 more sources

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Quantum Criticality via Magnetic Branes

, 2012
Holographic methods are used to investigate the low temperature limit, including quantum critical behavior, of strongly coupled 4-dimensional gauge theories in the presence of an external magnetic field, and finite charge density.
A. Donos, A. Donos, A.J. Millis, A.J. Millis, A.W. Rost, C. Fefferman, C.P. Herzog, D. Anninos, D.E. Kharzeev, D.T. Son, E. D’Hoker, E. D’Hoker, E. D’Hoker, E. D’Hoker, E. D’Hoker, E. Fradkin, E. Witten, G. Lifschytz, G. Policastro, H. Braviner, H. Liu, H.v. Lohneysen, I. Heemskerk, J. Boer de, J.A. Hertz, J.D. Brown, J.M. Maldacena, J.P. Gauntlett, K. Balasubramanian, K. Goldstein, N. Ogawa, N. Seiberg, O. Aharony, S. Haro de, S. Kachru, S. Nakamura, S. Sachdev, S.A. Hartnoll, S.A. Hartnoll, S.K. Domokos, S.S. Gubser, T. Andrade, T. Faulkner, T. Faulkner, T. Giamarchi, V. Balasubramanian, V. Balasubramanian, V. Oganesyan   +47 more
core   +1 more source

Fretting Fatigue Life Estimations Based on the Critical Distance Stress Theory

Procedia Engineering, 2011
AbstractGenerally fretting fatigue S-N curve have two stages, one is high cycle (low stress) region and second is low cycle (high stress) region. In previous paper we introduced the fretting fatigue life estimation methods in high cycle region by considering the wear process.
Hattori, Toshio, Wahab, Muhammad Amiruddin Bin Ab, Ishida, Takuya, Yamashita, Minoru   +3 more
openaire   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Book Review: Critical Digital Pedagogy in Higher Education

Open Praxis
This review of Critical Digital Pedagogy in Higher Education by Carlos Eduardo Flores Moreno explores the different sections and chapters presented in the book: “Shared Learning and Trust”, that focuses on alternative teaching methods; “Critical ...
Carlos Eduardo Flores Moreno
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Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source