Results 71 to 80 of about 1,891,729 (293)

On the multiaxial fatigue assessment of complex three-dimensional stress concentrators [PDF]

, 2014
This paper assesses and quantifies the detrimental effects of complex tri-dimensional notches subjected to uniaxial and multiaxial fatigue loading. A number of experimental results taken from the technical literature and generated by testing specimens ...
ASKES, Harm, DRAPER, John, GERIN, Benjamin, LOUKS, Richard, SUSMEL, Lucas   +4 more
core   +6 more sources

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Contextualism in Normative Political Theory and the Problem of Critical Distance [PDF]

Ethical Theory and Moral Practice, 2019
Political theory is contextualist when factual claims about context are part of the justification of normative political judgments. There are different kinds of contextualism depending on whether context is relevant for the formulation and justification of political principles (methodological contextualism), whether principles themselves are ...
openaire   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Take AIM and Keep Your Students Engaged

Journal of Open, Flexible and Distance Learning, 2014
This paper outlines the benefits to distance education teachers of formatting a weekly online newsletter in accordance with motivational learning theory.
Catherine Theresa Mary Nash
doaj   +2 more sources

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Fretting Fatigue Life Estimations Based on the Critical Distance Stress Theory

Procedia Engineering, 2011
AbstractGenerally fretting fatigue S-N curve have two stages, one is high cycle (low stress) region and second is low cycle (high stress) region. In previous paper we introduced the fretting fatigue life estimation methods in high cycle region by considering the wear process.
Hattori, Toshio, Wahab, Muhammad Amiruddin Bin Ab, Ishida, Takuya, Yamashita, Minoru   +3 more
openaire   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Book Review: Critical Digital Pedagogy in Higher Education

Open Praxis
This review of Critical Digital Pedagogy in Higher Education by Carlos Eduardo Flores Moreno explores the different sections and chapters presented in the book: “Shared Learning and Trust”, that focuses on alternative teaching methods; “Critical ...
Carlos Eduardo Flores Moreno
doaj   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source