Results 51 to 60 of about 397,795 (293)

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Study on dynamic characteristics of saturated loess with liquefied flow-slide induced by Jishishan earthquake in Zhongchuan, Qinghai Province

Yantu gongcheng xuebao
The 2023 Jishishan Mw6.2 earthquake induced the liquefaction flow slip of loess in Zhongchuan Township. In order to reveal its low-angle long-distance slip mechanism, based on the dynamic triaxial tests and microstructure analysis of undisturbed ...
JIA Shichao 1, ZHONG Xiumei 2, WANG Qian 2, WANG Yi 1, WANG Yan 2, HU Xuefeng 2
doaj   +1 more source

Hot Deformation Behavior of Powder Metallurgy Ti-14Mo-2.1Ta-0.9Nb-7Zr Alloy

Cailiao gongcheng, 2018
The new medical Ti-14Mo-2.1Ta-0.9Nb-7Zr alloy was prepared by powder metallurgy. The high temperature compression behavior and the dynamic recrystallization behavior of the alloy were investigated by hot compression tests. The tests were performed with a
MA Lin, LI Wei, BAI Jiao-jiao, ZHAO Feng-ting   +3 more
doaj   +1 more source

An experimental study of dynamic parameters of unit cell of deep mixed column-reinforced soft clay under dynamic loading

Shuiwen dizhi gongcheng dizhi, 2022
Composite soil with deep mixed column is widely used in strengthening soft soil subgrade. However, there is still a lack of understanding the dynamic characteristics of composite soil with deep mixed column and evaluating unreasonably the long-term ...
Guanbao YE, Liangkai QIN, Zhen ZHANG, Wenqiang ZHENG, Yong CHEN   +4 more
doaj   +1 more source

Safe dynamic design of structures. [PDF]

, 2000
The Design of structures under dynamic loading is a demanding subject in safety of engineering design since conventional static failure criteria are unable to deal with structures under transient loading.
Moatamedi, Mojtaba, Moatamedi, M.
core  

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Investigation on Dynamic Stability of Cement-Stabilized Expansive Soil Subgrades Subjected to Repeated Heavy-Haul Train Loads

Advances in Civil Engineering
The dynamic characteristics of the filler are intricately linked to the stability of the subgrade. In this investigation, relying on Haoji (Haolebaoji-Ji’an, China) heavy-haul railway engineering, cyclic triaxial tests were executed to scrutinize the ...
Yonghui Shang, Linrong Xu, Xiaofei Hao, Qichuan Zhu, Donghong Li   +4 more
doaj   +1 more source