Results 51 to 60 of about 388,704 (251)

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Micromechanics-based evaluation of strain rate effect on direct tensile failure in brittle rocks during dynamic geohazards

Geohazard Mechanics
Brittle rocks exhibit significantly lower dynamic direct tensile strength compared to their compressive strength, and the tensile strength is relatively difficult to be quantitatively measured through experiments.
Xiaozhao Li, Huaiwei Yan, Qiulin Luo, Chengzhi Qi   +3 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Review on Stress-Strain Rate Controllable Loading of Functionally Graded Materials

Gaoya wuli xuebao
Given the dependence that key material dynamic properties in critical fields (e.g., national defense security and high-end manufacturing) have on stress-strain rate-controlled loading.
Chengcheng GUO, Ruizhi ZHANG, Zhiqiang LIU, Zihao HUANG, Jian ZHANG, Guoqiang LUO, Qiang SHEN   +6 more
doaj   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Inferring Fault Frictional and Reservoir Hydraulic Properties From Injection‐Induced Seismicity

Geophysical Research Letters, 2018
Characterizing the rheological properties of faults and the evolution of fault friction during seismic slip are fundamental problems in geology and seismology.
Jayanth Jagalur‐Mohan, Birendra Jha, Zheng Wang, Ruben Juanes, Youssef Marzouk   +4 more
doaj   +1 more source

Critical Time Points Identification Method for Solution Space of Dynamic Stress Based on Spectral Element

Jixie Gongcheng Xuebao/Chinese Journal of Mechanical Engineering, 2014
exaly   +2 more sources

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Telomere Dynamics in Post-Traumatic Stress Disorder: A Critical Synthesis

Biomedicines
Post-traumatic stress disorder (PTSD), a mental disorder caused by exposure to traumatic stress, affects 5–10% of the world’s population. There is some evidence that PTSD is associated with accelerated cellular aging, leading to an increased risk of medical and neurodegenerative comorbidities.
openaire   +3 more sources

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source