Results 121 to 130 of about 5,911,268 (324)

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Excitation spectrum and magnetic field effects in a quantum critical spin-orbital system: The case ofFeSc2S4 [PDF]

, 2009
Gang Chen, Andreas P. Schnyder, Leon Balents   +2 more
openalex   +1 more source

Magnetic order and crystalline electric field excitations of the quantum critical heavy fermion ferromagnet CeRh$_6$Ge$_4$ [PDF]

, 2021
Jiangzheng Shu, D. T. Adroja, A. D. Hillier, Yongjun Zhang, Y. X. Chen, Bin Shen, Fabio Orlandi, H. C. Walker, Y. Liu, Chao Cao, F. Steglich, Huiqiu Yuan, M. Smidman   +12 more
openalex   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Efficient single-photon emission via quantum-confined charge funneling to quantum dots

Communications Materials
Quantum light sources, particularly single-photon emitters (SPEs), are critical for quantum communications and computing. Among them, III-V semiconductor quantum dots (QDs) have demonstrated superior SPE metrics, including near-unity brightness, high ...
Sanghyeok Park, Khalifa M. Azizur-Rahman, Darryl Shima, Ganesh Balakrishnan, Jaeyeon Yu, Hyunseung Jung, Jasmine J. Mah, Samuel Prescott, Pingping Chen, Sadhvikas Addamane, Douglas Pete, Andrew Mounce, Ting Shan Luk, Prasad P. Iyer, Igal Brener, Oleg Mitrofanov   +15 more
doaj   +1 more source

Magnetic Field Dependence of Excitations Near Spin-Orbital Quantum Criticality [PDF]

, 2017
Alun Biffin, Christian Rüegg, J. Embs, T. Guidi, Denis Cheptiakov, A. Loidl, V. Tsurkan, R. Coldea   +7 more
openalex   +1 more source

Cotargeting TREM2 and IL2 pathways triggers multipronged anticancer immunity

Molecular Oncology, EarlyView.
Von Locquenghien et al. report that MiTE‐144, a triggering receptor expressed on myeloid cells 2 (TREM2) blocking antibody fused to interleukin‐2 (IL2) variant with tumour microenvironment restricted activation, demonstrates superior anticancer efficiency in a preclinical setting.
Isaure Vanmeerbeek, Jenny Sprooten, Abhishek D. Garg   +2 more
wiley   +1 more source

Age and sex modulate scapular muscle excitation strategies during loaded shoulder flexion

Experimental Gerontology
Age and sex are primary risk factors for shoulder pain, yet the underlying neuromuscular adaptations in scapular control are poorly understood, partly due to methodological inconsistencies in prior research, particularly in load standardization.
Josée Rochon, Sarah Bohunicky, Trisha Scribbans   +2 more
doaj   +1 more source

Emergence of soft quark excitations by the coupling with a soft mode of the QCD critical point [PDF]

, 2014
Masakiyo Kitazawa, Teiji Kunihiro, Yukio Nemoto   +2 more
openalex   +1 more source