Results 41 to 50 of about 28,838 (310)
Making tau amyloid models in vitro: a crucial and underestimated challenge
FEBS Letters, EarlyView.This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley +1 more source
FEBS Letters, EarlyView.Dimeric pyruvate formate‐lyase cleaves pyruvate using a radical‐based mechanism. G734 serves as a radical storage location, and the radical is transferred to the catalytic C419 residue. Mutation of the C418‐C419 pair causes loss of enzyme activity, but does not impede radical introduction onto G734. Therefore, cis‐ but not trans‐radical transfer occurs
Michelle Kammel +2 more
wiley +1 more source
Existence and nonexistence of solutions for an approximation of the Paneitz problem on spheres
Boundary Value Problems, 2023 This paper is devoted to studying the nonlinear problem with slightly subcritical and supercritical exponents ( S ± ε ) : Δ 2 u − c n Δ u + d n u = K u n + 4 n − 4 ± ε $(S_{\pm \varepsilon}): \Delta ^{2}u-c_{n}\Delta u+d_{n}u = Ku^{ \frac{n+4}{n-4}\pm ...
Kamal Ould Bouh
doaj +1 more source
Planar random-cluster model: scaling relations
Forum of Mathematics, Pi, 2022 This paper studies the critical and near-critical regimes of the planar random-cluster model on $\mathbb Z^2$ with cluster-weight $q\in [1,4]$ using novel coupling techniques.
Hugo Duminil-Copin, Ioan Manolescu
doaj +1 more source
Molecular Oncology, EarlyView.This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini +10 more
wiley +1 more source
On critical exponents for self-similar collapse [PDF]
Journal of High Energy Physics, 2020 Abstract We explore systematically perturbations of self-similar solutions to the Einstein-axion-dilaton system, whose dynamics are invariant under spacetime dilations combined with internal 𝔰𝔩(2, ℝ) transformations. The self-similar solutions capture the enticing behavior “critical” systems on the verge of gravitational collapse ...
Riccardo Antonelli, Ehsan Hatefi
openaire +5 more sources
Molecular Oncology, EarlyView.This article advocates integrating temporal dynamics into cancer research. Rather than relying on static snapshots, researchers should increasingly consider adopting dynamic methods—such as live imaging, temporal omics, and liquid biopsies—to track how tumors evolve over time.
Gautier Follain +3 more
wiley +1 more source
Landscape of BRAF transcript variants in human cancer
Molecular Oncology, EarlyView.We investigate the annotation of BRAF variants, focusing on protein‐coding BRAF‐220 (formerly BRAF‐reference) and BRAF‐204 (BRAF‐X1). The IsoWorm pipeline allows us to quantify these variants in human cancer, starting from RNA‐sequencing data. BRAF‐204 is more abundant than BRAF‐220 and impacts patient survival.
Maurizio S. Podda +5 more
wiley +1 more source
Universality versus nonuniversality in asymmetric fluid criticality
Condensed Matter Physics, 2013 Critical phenomena in real fluids demonstrate a combination of universal features caused by the divergence of long-range fluctuations of density and nonuniversal (system-dependent) features associated with specific intermolecular interactions ...
M.A. Anisimov
doaj +1 more source
Meson excitation time as a probe of holographic critical point
European Physical Journal C: Particles and Fields, 2023 We study the time evolution of expectation value of Wilson loop as a non-local observable in a strongly coupled field theory with a critical point at finite temperature and nonzero chemical potential, which is dual to an asymptotically AdS charged black ...
Ali Hajilou
doaj +1 more source