Results 41 to 50 of about 290,989 (292)

A Cre‐dependent lentiviral vector for neuron subtype‐specific expression of large proteins

open access: yesFEBS Letters, EarlyView.
We designed a versatile and modular lentivector comprising a Cre‐dependent switch and self‐cleaving 2A peptide and tested it for co‐expression of GFP and a 2.8 kb gene of interest (GOI) in mouse cortical parvalbumin (PV+) interneurons and midbrain dopamine (TH+) neurons.
Weixuan Xue   +6 more
wiley   +1 more source

On the Aizenman exponent in critical percolation

open access: yes, 2002
The probabilities of clusters spanning a hypercube of dimensions two to seven along one axis of a percolation system under criticality were investigated numerically.
A. Bunde   +16 more
core   +1 more source

EGFR‐STAT3 activation provides a therapeutic rationale for targeting aggressive ETV1‐positive prostate cancer

open access: yesMolecular Oncology, EarlyView.
Cotargeting EGFR and STAT3 with Erlotinib and TTI‐101 impairs both 2D and 3D growth of ETV1‐overexpressing prostate cancer cells by disrupting a self‐sustaining ETV1–EGFR positive feedback loop that promotes EGFR and STAT3 expression and phosphorylation (activation).
Elsa Gomes Paiva   +5 more
wiley   +1 more source

Critical behaviour in gravitational collapse of radiation fluid --- A renormalization group (linear perturbation) analysis --- [PDF]

open access: yes, 1995
A scenario is presented, based on renormalization group (linear perturbation) ideas, which can explain the self-similarity and scaling observed in a numerical study of gravitational collapse of radiation fluid.
A. M. Abrahams   +9 more
core   +2 more sources

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

open access: yesMolecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero   +8 more
wiley   +1 more source

Hypergeometric continuation of divergent perturbation series: I. Critical exponents of the Bose–Hubbard model

open access: yesNew Journal of Physics, 2017
We study the connection between the exponent of the order parameter of the Mott insulator-to-superfluid transition occurring in the two-dimensional Bose–Hubbard model, and the divergence exponents of its one- and two-particle correlation functions.
Sören Sanders, Martin Holthaus
doaj   +1 more source

Field-induced tricritical phenomenon and magnetic structures in magnetic Weyl semimetal candidate NdAlGe

open access: yesNew Journal of Physics, 2022
Non-centrosymmetric NdAlGe is considered to be a candidate for magnetic Weyl semimetal in which the Weyl nodes can be moved by magnetization. Clarification of the magnetic structures and couplings in this system is thus crucial to understand its magnetic
Jun Zhao   +13 more
doaj   +1 more source

Critical exponents of the driven elastic string in a disordered medium

open access: yes, 2005
We analyze the harmonic elastic string driven through a continuous random potential above the depinning threshold. The velocity exponent beta = 0.33(2) is calculated.
H. Gao   +4 more
core   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

open access: yesMolecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts   +8 more
wiley   +1 more source

Existence and nonexistence of solutions for an approximation of the Paneitz problem on spheres

open access: yesBoundary Value Problems, 2023
This paper is devoted to studying the nonlinear problem with slightly subcritical and supercritical exponents ( S ± ε ) : Δ 2 u − c n Δ u + d n u = K u n + 4 n − 4 ± ε $(S_{\pm \varepsilon}): \Delta ^{2}u-c_{n}\Delta u+d_{n}u = Ku^{ \frac{n+4}{n-4}\pm ...
Kamal Ould Bouh
doaj   +1 more source

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