Results 111 to 120 of about 856,163 (286)
FEBS Letters, EarlyView.This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley +1 more source
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Improving the early life outcomes of Indigenous children: implementing early childhood development at the local level [PDF]
, 2013 One of Australia’s greatest challenges is the elimination of the gap between the developmental outcomes of Indigenous and non-Indigenous children in the early years of life.
WISE, S, Sarah Wise
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The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
Investigation of the critical illness gap in Singapore. [PDF]
, 2009 Critical illness has been a pressing issue around the world for a long time. The number of people contracting critical illnesses has been increasing rapidly and medical costs incurred by critical illnesses can be substantial.
Taruna Ishuwar Dass. +2 more
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FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
Teknik, 2012 This study want to measure the performance of pedestrian facilities ( zebra cross), particularly the critical gapanalysis to see the level of opportunity to cross the street safely.
Y.I. Wicaksono, Joko Siswanto
doaj
BuildingsPeru has experienced significant growth but faces challenges with its infrastructure. Despite economic and population growth, competitiveness has not risen at the same pace. The importance of proper roads for economic development and the lack of planning
Diego Cisneros-Herrera +3 more
doaj +1 more source
FEBS Letters, EarlyView.The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson +6 more
wiley +1 more source
Closing the gap - a regeneration strategy for Scotland? [PDF]
, 2002 There is a lengthy list of Scottish regeneration initiatives going back many years. Despite this, progress in bringing about lasting change often seems to have been limited.
Hayton, Keith
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