Results 201 to 210 of about 8,191,239 (342)

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

National Online Peer Support for People Recovering From Critical Illness and Their Families: A Study Protocol. [PDF]

open access: yesActa Anaesthesiol Scand
Kjær MN   +8 more
europepmc   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

Relations between ethnic-racial identity statuses and critical consciousness among Latine adolescents. [PDF]

open access: yesJ Res Adolesc
Wantchekon KA   +6 more
europepmc   +1 more source

The Critical Role of the 2’-OH group in Phase Separation and Percolation Transitions of RNA [PDF]

open access: gold
Priya R. Banerjee   +4 more
openalex   +1 more source

Catalytically critical nucleotide in domain 5 of a group II intron. [PDF]

open access: bronze, 1995
Craig L. Peebles   +3 more
openalex   +1 more source

Critical periods in group development.

open access: yesPeace and Conflict: Journal of Peace Psychology, 2021
openaire   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

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