Results 241 to 250 of about 8,178,562 (344)

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Cooperative spatial modelling of hospital compliance with minimum caseload requirements. [PDF]

Int J Health Geogr
Ji L, Geraedts M, de Cruppé W.
europepmc   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

A cluster analysis of operating room nurses' profiles based on their clinical decision-making for pressure injury prevention. [PDF]

Front Public Health
Guo ZS, Wang XM, Fan HL, Wei L, Zhang X, Guo Y, Niu YB, Li YJ.   +7 more
europepmc   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Correction: Discarded intravenous medication in the ICU: the GAME-OVER multicenter prospective observational study. [PDF]

Crit Care
d'Aranda E, GAME-OVER investigators group, Pons S, Chelly J, Atchade E, Bonnet L, SFAR Sustainable Development Committee, Dahyot-Fizelier C, SFAR Critical Care Committee, Kamel T, Giannoni F, Collange O, Besnier E, Schoeffler M, Mayeur N, Quere PL, Marecal L, Pernod C, Geay C, Esnault P, Cinotti R, SFAR Research Network, Cesana M, Cungi PJ.   +23 more
europepmc   +1 more source

Erratum: Workshop to Identify Critical Windows of Exposure for Children's Health: Cancer Work Group Summary

, 2000

openalex   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Continuous Flipped Classroom in Anesthesiology: Enhancing Learning Outcomes and Anesthesiology Major Selection in Eight-Year Program Students. [PDF]

Adv Med Educ Pract
Hu ZL, Hu YZ, Gao ZJ, Luo YW, Ou P, Luo C, Cui YH, Luo RY.   +7 more
europepmc   +1 more source