Results 81 to 90 of about 2,498,418 (268)

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham   +21 more
wiley   +1 more source

Multiple solutions to asymmetric semilinear elliptic problems via Morse theory

open access: yesElectronic Journal of Differential Equations, 2014
In this article we study the existence of solutions to the problem $$\displylines{ -\Delta u = g(x,u) \quad \text{in } \Omega; \cr u = 0 \quad\text{on } \partial\Omega, }$$ where $\Omega$ is a smooth bounded domain in $\mathbb{R}^N$ $(N\geq 2)$
Leandro L. Recova, Adolfo J. Rumbos
doaj  

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

open access: yesMolecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan   +9 more
wiley   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

open access: yesMolecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts   +8 more
wiley   +1 more source

A weighted (p,2)-equation with double resonance

open access: yesElectronic Journal of Differential Equations, 2023
Zhenhai Liu, Nikolaos S. Papageorgiou
doaj  

Multiplicity of solutions for gradient systems

open access: yesElectronic Journal of Differential Equations, 2010
We establish the existence of nontrivial solutions for an elliptic system which is resonant both at the origin and at infinity. The resonance is given by an eigenvalue problem with indefinite weight, and the nonlinear term is permitted to be unbounded.
Edcarlos D. Da Silva
doaj  

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira   +14 more
wiley   +1 more source

Alienation – a long-overlooked concept of relevance to social work?

open access: yesSocial Work and Society, 2019
Alienation is seemingly a relevant concept in social work in so far as this concerns marginalized and vulnerable groups of people. Nevertheless, the interest in alienation theory has declined within social science as a whole, partly due to postmodern ...
Henrik Skovlund
doaj   +2 more sources

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