Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Lower-order perturbations of critical growth nonlinearities in semilinear elliptic equations [PDF]
, 1997 Filippo Gazzola, Bernhard Ruf
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Single--peaks for a magnetic Schr\"{o}dinger equation with critic al growth
, 2006 We prove existence results of complex-valued solutions for a semilinear Schr\"odinger equation with critical growth under the perturbation of an external electromagnetic field.
Barile, S., Cingolani, S., Secchi, S.
core
Mechanisms of parasite‐mediated disruption of brain vessels
FEBS Letters, EarlyView.Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira +3 more
wiley +1 more source
Plant analysis as a tool to determine crop nitrogen status [PDF]
, 2007 An effective plant nutrient management strategy optimises nitrogen (N) use efficiency for minimised environmental impact, while ensuring an optimum N status of the crop for good product quality and maximum growth.
Ekbladh, Göran
core
β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source
Ground state solutions for asymptotically periodic Schrodinger equations with critical growth
Electronic Journal of Differential Equations, 2013 Using the Nehari manifold and the concentration compactness principle, we study the existence of ground state solutions for asymptotically periodic Schrodinger equations with critical growth.
Hui Zhang, Junxiang Xu, Fubao Zhang
doaj
Platelet-derived Growth Factor (PDGF) Receptor-α-activated c-Jun NH2-terminal Kinase-1 Is Critical for PDGF-induced p21 Promoter Activity Independent of p53 [PDF]
, 2003 Jiuhong Yu +2 more
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Molecular Oncology, EarlyView.AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou +5 more
wiley +1 more source
Existence of Solutions for a Perturbed N-Laplacian Boundary Value Problem with Critical Growth
AxiomsIn this paper, we investigate a perturbed elliptic boundary value problem that exhibits critical growth characterized by a Trudinger–Moser-type inequality. Our primary focus is to establish the existence of two nontrivial solutions.
Sheng Shi, Yang Yang
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