Results 61 to 70 of about 388,085 (306)

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Critical Heat Flux in Nanofluids at Quasi-Stationary and Stepwise Heat Generation

MATEC Web of Conferences, 2016
In this paper results of an experimental study on critical heat flux in nanofluid at quasi-stationary and stepwise heat generation are presented. Freon R21 with addition of 0.0077 vol.% of SiO2 nanoparticles was used as test fluid.
Moiseev Mikhail, Zhukov Vladimir, Kuznetsov Denis   +2 more
doaj   +1 more source

Study on critical heat flux density at the quasi-stationary heating of superficially boiling binary mixtures

Advanced Engineering Research, 2015
The heat-flow rate and temperature of the heater are measured at various liquid subcooling boiling points. An experimental plant and the obtained results on the heat energy motion in the superficially boiling binary liquid mixtures are described.
Victor Vladimirovich Kozhokaru, Evgeny Vasilyevich Lykov   +1 more
doaj   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Experimental Study of Carbon Dioxide Boiling Crisis in Near-critical Natural Circulation

Yuanzineng kexue jishu
Carbon dioxide is utilized as a direct coolant in micro-modular gas-cooled fast reactor cycle systems. The supercritical carbon dioxide cycle systems are attracted widespread attention for their compact design and high operating efficiency.
ZENG Chengtian1, ZHOU Yuan1, HUANG Yanping2, LUO Qiao1, TIAN Gengyuan1, HUANG Jiajian1
doaj   +1 more source

Measurement of wetted area fraction in subcooled pool boiling of water using infrared thermography [PDF]

, 2013
The wetted area fraction in subcooled pool boiling of water at atmospheric pressure is measured using the DEPIcT (DEtection of Phase by Infrared Thermography) technique.
Buongiorno, Jacopo, Kim, Hyung Dae, Park, Youngjae   +2 more
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

An experimental study of thermocapillary rupture of a locally heated horizontal liquid layer on various substrates

MATEC Web of Conferences, 2017
This article experimentally studies a thermocapillary rupture of a locally heated horizontal liquid film on substrates of different materials and different thickness. In the course of work the dependence of the critical heat flux on the initial and final
Kochkin Dmitry
doaj   +1 more source

Experimental study of bubble behaviors and CHF on printed circuit board (PCB) in saturated pool water at various inclination angles

Nuclear Engineering and Technology, 2018
Experiments were performed to investigate bubble behaviors and pool boiling Critical Heat Flux (CHF) on a thin flat rectangular copper heater fabricated on Printed Circuit Board (PCB), at various inclination angles. The surface inclination angles were 0°,
Elvira F. Tanjung, Bernard O. Alunda, Yong Joong Lee, Daeseong Jo   +3 more
doaj   +1 more source