Results 41 to 50 of about 6,384,297 (281)
Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research
FEBS Letters, EarlyView.What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
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Advanced Engineering Research, 2015 The heat-flow rate and temperature of the heater are measured at various liquid subcooling boiling points. An experimental plant and the obtained results on the heat energy motion in the superficially boiling binary liquid mixtures are described.
Victor Vladimirovich Kozhokaru +1 more
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Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
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Experimental Study of Carbon Dioxide Boiling Crisis in Near-critical Natural Circulation
Yuanzineng kexue jishuCarbon dioxide is utilized as a direct coolant in micro-modular gas-cooled fast reactor cycle systems. The supercritical carbon dioxide cycle systems are attracted widespread attention for their compact design and high operating efficiency.
ZENG Chengtian1, ZHOU Yuan1, HUANG Yanping2, LUO Qiao1, TIAN Gengyuan1, HUANG Jiajian1
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Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
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Nuclear Engineering and Technology, 2018 Experiments were performed to investigate bubble behaviors and pool boiling Critical Heat Flux (CHF) on a thin flat rectangular copper heater fabricated on Printed Circuit Board (PCB), at various inclination angles. The surface inclination angles were 0°,
Elvira F. Tanjung +3 more
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Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
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MATEC Web of Conferences, 2017 This article experimentally studies a thermocapillary rupture of a locally heated horizontal liquid film on substrates of different materials and different thickness. In the course of work the dependence of the critical heat flux on the initial and final
Kochkin Dmitry
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Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
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Effect of Heating Orientation on the Critical Heat Flux of Flow Boiling
Zhileng xuebao, 2015 In order to research the effect of the gravity on the critical heat flux of flow boiling, a two-phase boiling heat transfer test system was established.
Li Gang +3 more
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