Results 51 to 60 of about 67,496 (315)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Experimental investigation of non-uniform heating effect on flow boiling instabilities in a microchannel-based heat sink

, 2011
Copyright @ 2011 ElsevierTwo-phase flow boiling in microchannels is one of the most promising cooling technologies for coping with high heat fluxes produced by the next generation of central processor units (CPUs).
Bogojevic, D, Cummins, G, Karayiannis, T. G., T.G. Karayiannis, Lin, H., H. Lin, D. Bogojevic, K. Sefiane, D.B.R. Kenning, A.J. Walton, G. Cummins, Lin, H, Sefiane, K, Sefiane, K., Walton, AJ, Walton, A. J., Cummins, G.; id_orcid, Bogojevic, D., Karayiannis, TG, Kenning, DBR, Kenning, D. B. R.   +20 more
core   +1 more source

Effect of Heating Orientation on the Critical Heat Flux of Flow Boiling

Zhileng xuebao, 2015
In order to research the effect of the gravity on the critical heat flux of flow boiling, a two-phase boiling heat transfer test system was established.
Li Gang, Song Baoyin, Zhang Zhao, Luo Zufen   +3 more
doaj  

Prediction models of critical heat flux for vertical downward flow

Nihon Kikai Gakkai ronbunshu, 2017
Critical heat flux is one of the most important key parameters for various boiling systems, such as nuclear reactors and conventional boilers. Thus, many investigations have been reported, but most of these are concerned with the upward flow condition ...
Yoshiki KAWAZOE, Takeyuki AMI, Hisashi UMEKAWA, Mamoru OZAWA   +3 more
doaj   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Experimental Study on Enhanced Boiling Heat Transfer on Micro-pin-fin Structures at High Degrees of Subcooling

Zhileng xuebao, 2023
In response to the power increase in electronic devices with high heat flux density, new efficient cooling technologies should be developed to ensure the safe operation of these electronic devices.
Wang Yueming, Lu Jingchao, Zhuang Dawei, Ding Guoliang   +3 more
doaj  

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Flow patterns and heat transfer for flow boiling in small to micro diameter tubes

, 2008
An overview of the recent developments in the study of flow patterns and boiling heat transfer in small to micro diameter tubes is presented. The latest results of a long-term study of flow boiling of R134a in five vertical stainless steel tubes of ...
Karayiannis, TG, Shiferaw, D, Kenning, DBR, Wadekar, VV   +3 more
core