Results 171 to 180 of about 510,057 (296)

Iron Metabolism: An Emerging Therapeutic Target in Critical Illness [PDF]

, 2019
Edward Litton, Jolene Lim
openalex   +1 more source

Focus on host/organ unregulated response: a common cause of critical illness

, 2022
Wei Huang, Dawei Liu, Hongmin Zhang, Xin Ding, Xiaoting Wang   +4 more
openalex   +1 more source

Refractory Status Epilepticus and Therapeutic Uncertainties: a Comprehensive Review on Targeting Neuroinflammation and Rationale for Developing a Platform Trial

Advanced Science, EarlyView.
Refractory status epilepticus (RSE) is a life‐threatening neurological emergency with high rates of death and long‐term disability, but treatments for it are often based on limited evidence. RSE is now understood to involve neuroinflammation, which has led to the exploration of anti‐inflammatory and immunomodulatory agents like Tocilizumab. Traditional
Shanika Samarasekera, Suneesh Thilak, Asha Patel, Prashant Nasa, Zubair Ahmed, Lorraine Jacques, William J. Scotton, Cyril Chacko, Randeep Mullhi, Ruoling Chen, Vikram Patil, Suresh Renukappa, Tonny Veenith   +12 more
wiley   +1 more source

Trajectories of Recovery after ACutE and cRitical illness (TRACER): a prospective observational study protocol. [PDF]

BMJ Open
González-Seguel F, Summers LA, Fresenko LE, Long DE, Scott LN, Slone SA, Shankara Bhaktula S, Wen Y, Miller BF, Morris PE, Salyer AL, Kalema AG, Montgomery-Yates AA, Dupont-Versteegden EE, Mayer KP, TRACER study group Collaborators.   +15 more
europepmc   +1 more source

Critical illness induces nutrient-independent adipogenesis and accumulation of alternatively activated tissue macrophages [PDF]

, 2013
Mirna Bastos Marques, Sarah Vander Perre, Annelies Aertgeerts, Sarah Derde, Fabián Güiza, Michaël P. Casaer, Greet Hermans, Greet Van den Berghe, Lies Langouche   +8 more
openalex   +1 more source

An Aptamer‐Based EXACT Anticoagulant as a Sustainable, Animal‐Free Alternative to Unfractionated Heparin

Advanced Science, EarlyView.
By simply conjugating thrombin's active‐site inhibitor, dabigatran, with an exosite inhibitor, aptamer HD1, the resulting EXosite‐ACTive site (EXACT) inhibitors show two orders of magnitude higher potency and selectivity via synergistic binding, while maintaining the aptamer's antidote‐reversible trait, yielding a potential substitute for the animal ...
Haixiang Yu, George Pitoc, Manqi Zhang, Jeffrey Clancy, James Frederiksen, Amy Yan, Samuel Francis, Rebecca Sullenger, Rachel Rempel, Susannah Gammell, Jillian Caiazzi, Bruce A. Sullenger   +11 more
wiley   +1 more source

Who is responsible for follow-up after critical illness? GP, ICU and patient perspectives. [PDF]

Crit Care
Stewart J, Anderson J, Mayne R, Bradley J, Hart N, Leggett N, McAuley D.   +6 more
europepmc   +1 more source

Single‐Cell Insights Into Macrophage Subtypes in Pulmonary Infections

Advanced Science, EarlyView.
This review highlights the dynamic plasticity of macrophages during pulmonary infections and proposes an integrative framework defining six functional subtypes: Inflam‐Ms, Hub‐Ms, Reg‐Ms, Prolif‐Ms, Memory‐Ms, and Senesc‐Ms. Single‐cell omics delineate their distinct roles in homeostasis and infection, refining our understanding of macrophage ...
Zhaoheng Lin, Yuxiao Zheng, Yu Zhong, Hongyan Wang   +3 more
wiley   +1 more source

From hospital to home: A heightened window of vulnerability post-critical illness. [PDF]

PLoS One
Howard AF, Lynch K, Thorne S, Currie LM, Arora RC, McDermid RC, Ahmad O, Crowe S, Hoiss S, David A, Chu J, Erchov A, Hou B, Singh A, Tsui M, Haljan G.   +15 more
europepmc   +1 more source

Astrocytic PERK Deficiency Drives Prefrontal Circuit Dysfunction and Depressive‐Like Behaviors

Advanced Science, EarlyView.
Chen et al. show that the endoplasmic reticulum (ER) stress sensor PERK is downregulated in prefrontal cortex (PFC) astrocytes in major depressive disorder and in chronic‐stress mouse models. In young mice, astrocyte‐specific PERK loss reduces the synaptogenic cue thrombospondin‐1 (TSP1), leading to synaptic and circuit deficits and depressive‐like ...
Kai Chen, Riya Gupta, Yosuke M. Morizawa, Yu Qin, Xingyu Du, Cynthia Pang, Osama Al‐Dalahmah, Maura B. Dupont, Guang Yang   +8 more
wiley   +1 more source