Results 171 to 180 of about 6,957,076 (388)

Tocilizumab is associated with reduced delirium and coma in critically ill patients with COVID-19

Scientific Reports
Recent preclinical studies demonstrate a direct pathological role for the interleukin-6 (IL-6) pathway in mediating structural and functional delirium-like phenotypes in animal models of acute lung injury.
Tuqa Alkhateeb, Joanna L. Stollings, Ine Sohn, Dandan Liu, L. Montana Fleenor, E. Wesley Ely, Shouri Lahiri   +6 more
doaj   +1 more source

The post-septic peripheral myeloid compartment reveals unexpected diversity in myeloid-derived suppressor cells

Frontiers in Immunology
IntroductionSepsis engenders distinct host immunologic changes that include the expansion of myeloid-derived suppressor cells (MDSCs). These cells play a physiologic role in tempering acute inflammatory responses but can persist in patients who develop ...
Evan L. Barrios, Jack R. Leary, Dijoia B. Darden, Jaimar C. Rincon, Micah Willis, Valerie E. Polcz, Gwendolyn S. Gillies, Jennifer A. Munley, Marvin L. Dirain, Ricardo Ungaro, Dina C. Nacionales, Marie-Pierre L. Gauthier, Shawn D. Larson, Laurence Morel, Tyler J. Loftus, Alicia M. Mohr, Robert Maile, Michael P. Kladde, Clayton E. Mathews, Maigan A. Brusko, Todd M. Brusko, Lyle L. Moldawer, Rhonda Bacher, Philip A. Efron   +23 more
doaj   +1 more source

Host‐Directed Biomaterials for Combatting Bloodstream Infections: From Macrocyclic Peptides to Immune‐Activating Cell Backpacks

Advanced Functional Materials, EarlyView.
Bloodstream infections (BSI) are one of the leading causes of mortality and morbidity in both civilian and military populations. This paper summarizes recent progress in novel treatment strategies to manage BSI arising from both bacterial and fungal pathogens using molecules, particles, and materials to elicit host‐directed immunity.
Thomas Thomou, Jagadish Krishnappa, Justin B. Schaal, Prasad Tongaonkar, Dat Q. Tran, Wenchao Gu, Yung‐Fu Chang, Michael E. Selsted, Shaoyi Jiang, Samir Mitragotri, Michael Super, Christopher J. Bettinger   +11 more
wiley   +1 more source

Sodium butyrate attenuates oxidative stress, apoptosis, and excessive mitophagy in sodium fluoride-induced hepatotoxicity in rats

Ecotoxicology and Environmental Safety
Aim: Long-term exposure to excess sodium fluoride (NaF) can cause chronic fluorosis. Liver, the most important detoxification organ, is the most vulnerable to the effects of fluoride.
Jing Xia, Xiaolin Zhang, Leiyu Xu, Nan Yan, Zhenxiang Sun, Xiaoxu Duan, Lu Meng, Rong Qi, Fu Ren, Zhengdong Wang   +9 more
doaj   +1 more source

Prevalence and Course of Frailty in Survivors of Critical Illness*

, 2020
Nathan E. Brummel, Timothy D. Girard, Pratik P. Pandharipande, Jennifer L. Thompson, Ryan T. Jarrett, Rameela Raman, Christopher G. Hughes, Mayur B. Patel, Alessandro Morandi, Thomas M. Gill, E. Wesley Ely   +10 more
openalex   +2 more sources

Patients with COVID-19 Critical Illness Have a Significantly Higher Systemic Immune-Inflammatory Index on Admission

, 2023
Fenty Fenty, Dita Maria Virginia, I Made Adi Ananda Putra, Devie Kristiani, Lisa Kuniasari   +4 more
openalex   +2 more sources

Clinical features and predictors of severity in COVID-19 patients with critical illness in Singapore [PDF]

, 2021
Ser Hon Puah, Barnaby Edward Young, Po Ying Chia, Vui Kian Ho, Jiashen Loh, Roshni Sadashiv Gokhale, Seow Yen Tan, Duu Wen Sewa, Shirin Kalimuddin, Chee Keat Tan, Surinder Pada, Matthew E. Cove, Louis Yi Ann Chai, Purnima Parthasarathy, Benjamin Ho, Jensen Ng, Li Min Ling, John Abisheganaden, Vernon J. M. Lee, Cher Heng Tan, Raymond T. P. Lin, Yee‐Sin Leo, David Chien Lye, Tsin Wen Yeo, Poh Lian Lim, Brenda Ang, Cheng Chuan Lee, Lawrence S. Lee, Oon Tek Ng, Mónica Chan, Kalisvar Marimuthu, Shawn Vasoo, Chen Seong Wong, Tau Hong Lee, Sapna P. Sadarangani, Susan Kline, Mucheli Sharavan Sadasiv, Deborah Hee Ling Ng, Chiaw Yee Choy, Glorijoy Shi En Tan, Yu Tan, Sean Wei Xiang Ong, Stephanie Sutjipto, Pei Hua Lee, Jun Yang Tay, Ding Ying, Bo Yan Khoo, Woo Chiao Tay, Gabrielle Ng, Yun Yuan Mah, Wilnard Tan, Sennen Jin Wen Lew, Raymond Fong, Helen May Lin Oh, Jaime Mei Fong Chien, Humaira Shafi, Hau Yiang Cheong, Darren Cheng Han Teo, Thuan Tong Tan, Ban Hock Tan, Jenny G. Low, Limin Wijaya, Indumathi Venkatachalam, Ying Ying Chua, Benjamin Pei Zhi Cherng, Yvonne Fu Zi Chan, Ghee Chee Phua, Ken Junyang Goh, Jade Xiao Jue Soh, Shuwei Zheng, Pushpalatha Bangalore Lingegowda, Wee Ming Peh, Yi Lin Lee, Jun Yang Ho, April Yu Jie Chia, Li Lin, Say Tat Ooi, Tambyah Paul Anantharajah, Jyoti Somani, Jolene Oon, Gabriel Yan   +80 more
openalex   +1 more source

Reevaluating the Activity of ZIF‐8 Based FeNCs for Electrochemical Ammonia Production

Advanced Functional Materials, EarlyView.
Though receiving much attention, the field of electrochemical nitrogen reduction reaction (eNRR) to ammonia is marked by doubts about whether this reaction is possible in aqueous media. This work sheds light on this question for iron single‐atom on N‐doped carbon (FeNC) catalysts—a class of well‐known catalysts that is also worth testing for the sister
Caroline Schneider, S. Esmael Balaghi, Niklas Ortlieb, Patrick Elsaesser, Sima Heidari, Christopher S. Allen, Anna Fischer   +6 more
wiley   +1 more source

Interleukin-6: obstacles to targeting a complex cytokine in critical illness

The Lancet Respiratory Medicine, 2021
O. McElvaney, G. Curley, S. Rose-John, N. McElvaney   +3 more
semanticscholar   +1 more source

A Bespoke Programmable Interpenetrating Elastomer Network Composite Laryngeal Stent for Expedited Paediatric Laryngotracheal Reconstruction

Advanced Functional Materials, EarlyView.
A programmable interpenetrating double‐network architecture, created via 3D‐TIPS printing and resin infusion, synergistically combines thermoplastic and thermosetting elastomers to balance structural rigidity and surface softness—crucial for paediatric laryngeal stents.
Elizabeth F. Maughan, Lei Wu, Dong Zhang, Linxiao Wu, Graca Ferreira Vaz Pinto Mendes, Wanqiao J. Tu, Heping Ma, Toby J. Proctor, Colin R. Butler, Thomas Kjærgaard, Mark W. Lowdell, Martin A. Birchall, Robert E. Hynds, Richard Hewitt, Wenhui Song   +14 more
wiley   +1 more source