Results 271 to 280 of about 6,957,076 (388)

Astrocytic PCBP1 Suppresses Ferroptosis to Restore Glutamatergic Homeostasis and Mitigate Stress‐Induced Depression in Male Mice

open access: yesAdvanced Science, EarlyView.
This study demonstrates that polyC‐RNA‐binding protein 1 (PCBP1) in ventral hippocampal astrocytes modulates depressive‐like behaviors by regulating glutathione peroxidase 4‐mediated ferroptosis and synaptic glutamatergic transmission. PCBP1 overexpression intervention in the chronic unpredictable mild stress model rescues behavioral deficits ...
Jinyu Zhang   +15 more
wiley   +1 more source

Population‐Based Multi‐Omics and Cohort Study Identifying Predictive Biomarkers and Therapeutic Targets for Psoriatic Disease

open access: yesAdvanced Science, EarlyView.
Psoriatic disease (PsD) is a chronic skin disease, with challenges in early risk stratification and drug development. Through gene‐level causal inference framework and expression level validation, combined with longitudinal cohort study, CDSN and PRSS8 have been identified as candidate biomarkers and therapeutic targets for PsD.
Tianxing Wu   +13 more
wiley   +1 more source

Evidence for Persistent Immune Suppression in Patients Who Develop Chronic Critical Illness After Sepsis

open access: green, 2017
Julie A. Stortz   +17 more
openalex   +2 more sources

A Clarification on Quantum‐Metric‐Induced Nonlinear Transport

open access: yesAdvanced Science, EarlyView.
How does the quantum metric truly govern the nonlinear transport? The longstanding theoretical discrepancies are resolved in quantum‐metric‐induced nonlinear transport and the correct intrinsic nonlinear conductivity is identified. Furthermore, a toy model is engineered to suppress the competing effects, uniquely highlighting the role of quantum metric
Xiao‐Bin Qiang   +4 more
wiley   +1 more source

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