Results 281 to 290 of about 6,679,818 (388)

Timing of onset of persistent critical illness in Japan: a nationwide registry study. [PDF]

Lancet Reg Health West Pac
Ohbe H, Kudo D, Kobayashi N, Shirasaki K, Nakamura K, Iwashyna TJ, Kushimoto S.   +6 more
europepmc   +1 more source

Allele‐Specific Regulation of PAXIP1‐AS1 by SMC3/CEBPB at rs112651172 in Psychiatric Disorders Drives Synaptic and Behavioral Dysfunctions in Mice

Advanced Science, EarlyView.
This study identifies a functional noncoding variant, rs112651172 (C/G), that drives allele‐specific expression of PAXIP1‐AS1 in monozygotic twin pairs discordant for schizophrenia and bipolar disorder. The risk G allele enhances CEBPB binding, leading to lncRNA upregulation, CNTNAP3 derepression, and synaptic and behavioral deficits in mice.
Chaoying Ni, He Chen, Qiaqi Chen, Yangyang Liao, Yunqian Wang, Linyan Ye, Xiaohui Wu, Hongyu Ni, Tingyun Jiang, Shufen Li, Qiong Yang, Hong Xue, Zhongju Wang, Feng Yi, Cunyou Zhao   +14 more
wiley   +1 more source

Fluid therapy in critical illness [PDF]

, 2014

core   +1 more source

Friend or foe: the gut microbiota as a modulator of disease trajectory in trauma, surgery, and critical illness. [PDF]

Gut Microbes
Cao J, Meltzer R, Cohn E, Benjamin A, Keskey R, Alverdy J.   +5 more
europepmc   +1 more source

Metabolic Interplay in Acute Lung Injury: PARK7 Integrates FADS1/2‐Dependent PUFA Metabolism and H3K14 Lactylation to Attenuate Endothelial Ferroptosis and Dysfunction

Advanced Science, EarlyView.
SCAP/ARDS patients show reduced unsaturated fatty acids (UFAs) but higher PARK7 and lactate in plasma. PARK7 correlates positively with lactate and negatively with UFAs. Pulmonary endothelial cell multi‐omics show FADS1/2 downregulation and impaired PUFA metabolism. Lactate boosts PARK7 via H3K14 lactylation, and PARK7 then restores FADS1/2.
Jian Xu, Yuhan Wang, Weiqi Mao, Tianchang Wei, Yufan Li, Juan Song, Cuiping Zhang, Xiaoyan Chen, Cuicui Chen, Qingyuan Xu, Xu Wu, Yuanlin Song   +11 more
wiley   +1 more source

A Patient Suffered from Critical Illness Polyneuropathy during the Treatment of Status Asthmaticus.

, 2001
Sayoko Takekida, Osamu Tanaka, Hiroaki KOGANEI, Yoshio Horikawa, Katsuhiro Iijima, Suwako KAWAKAMI, Hidefumi Obara, Hisashi Ohnishi, Taro Morimoto, Chie Yanagihara   +9 more
openalex   +2 more sources

Mechanical power and VILI: navigating heterogeneity in critical illness. [PDF]

Intensive Care Med Exp
Plens GM, Costa ELV.
europepmc   +1 more source

Novel Swelling‐Lytic Cell Death Triggered by Cargo‐Free Ionizable Lipid Nanoparticles

Advanced Science, EarlyView.
A cargo‐free ionizable lipid nanoparticles (ipLNP) is found to induce broad swelling‐lytic cell death across multiple cell types. Cell death may be associated with lysosome membrane destabilization, involving ROS increase, lipid peroxidation, and GSDME cleavage.
Junjun Wu, Zhennan Zhao, Hongsheng Wu, Sihuang Lin, Lin Huang, Guanjie Chen, Yi Yang, Hong Wang, Huijie Yan, Yonghui Shi, Liuyu Zhu, Guosheng Hu, Liling Zheng, Songying Ouyang   +13 more
wiley   +1 more source

Mechanisms of Organ Dysfunction in Critical Illness

, 2002
David J. Dries
openalex   +1 more source

Guidelines for the diagnosis and management of critical illness-related corticosteroid insufficiency (CIRCI) in critically ill patients (Part I): Society of Critical Care Medicine (SCCM) and European Society of Intensive Care Medicine (ESICM) 2017

Intensive Care Medicine, 2018
D. Annane, S. Pastores, B. Rochwerg, W. Arlt, R. Balk, A. Beishuizen, J. Briegel, J. Carcillo, M. Christ-Crain, M. Cooper, P. Marik, G. Umberto Meduri, K. Olsen, Sophia Rodgers, J. Russell, G. Van den Berghe   +15 more
semanticscholar   +1 more source