Results 301 to 310 of about 6,679,818 (388)

Effect of an Educational Intervention on Nurses' Knowledge Regarding Use of Modified Early Warning Score in Recognition of Critical Illness. [PDF]

Open Access Emerg Med
Olowo S, Luwaga R, Niyonzima V.
europepmc   +1 more source

SLC6A14 Drives Mitochondrial Fusion and Oxidative Phosphorylation to Promote Cancer Stemness and Early‐Onset of Breast Cancer

Advanced Science, EarlyView.
Elevated levels of the plasticizer DEHP associate with earlier breast cancer diagnosis. DEHP enhances glutamine‐powered energy production via the transporter SLC6A14 and pushes mitochondria toward fusion, driving tumor initiation by boosting cancer stemness. Blocking SLC6A14 lowers stemness, slows tumors, and improves chemotherapy response.
Dai‐Wei Hu, Chih‐Hao Huang, Yu‐Hao He, Ya‐Ling Wei, Shu‐Wei Hu, Fang‐Ju Cheng, Thanh Kieu Huynh, Bo‐Rong Chen, Bo‐Wei Wang, Li‐Chi Kuan, Der‐Yen Lee, Ming‐Hsin Yeh, Ya‐Jen Chang, Liang‐Chih Liu, Mien‐Chie Hung, Wei‐Chien Huang   +15 more
wiley   +1 more source

Muscle weakness after critical illness: unravelling biological mechanisms and clinical hurdles. [PDF]

Crit Care
Pierre A, Favory R, Bourel C, Howsam M, Romien R, Lancel S, Preau S.   +6 more
europepmc   +1 more source

Rethinking the AI Paradigm for Solubility Prediction of Drug‑Like Compounds with Dual‐Perspective Modeling and Experimental Validation

Advanced Science, EarlyView.
Aqueous solubility governs drug delivery and bioavailability, yet its prediction remains challenging. Utilizing the largest curated dataset of drug‐like molecules, prediction models are constructed through dual‐perspective benchmarking. Stacking methods outperform advanced deep learning due to data constraints. These validated models enabled systematic
Qilin Zhu, Yuxin Qiu, Guzhong Chen, Wenyao Chen, Xiang Zhang, Zhiwen Qi, Xuezhi Duan, De Chen, Zhen Song   +8 more
wiley   +1 more source

Association between acute kidney injury, delirium and outcomes in patients with critical illness: a protocol for a systematic review. [PDF]

BMJ Open
Kusirisin P, Kung JY, Corsaro A, Rewa O, Wilcox ME, Bagshaw SM.   +5 more
europepmc   +1 more source

A Modern Roman‐Inspired Concrete with Daytime Radiative Cooling Capacity

Advanced Science, EarlyView.
Coolcrete, inspired by ancient Roman concrete, is a new cementitious material with photonic properties enabling passive daytime radiative cooling. Made from quicklime and zeolites, it reduces cooling energy demand, lowers CO2 emissions, and may eliminate urban heat islands.
Jorge S. Dolado, Guido Goracci, Ghizlane Moutaoukil, Ridwan O. Agbaoye, Miguel Beruete, Alicia E. Torres‐García, Laura Carlosena, Achutha Prabhu, Jose A. Ibáñez, Nick Adams, Nicole van Lipzig, Karen Allacker   +11 more
wiley   +1 more source

Correlation of Neutrophil-Lymphocyte Ratio and Critical Illness in Adults on Vancomycin: A Cross-Sectional Study. [PDF]

Int J Gen Med
Alfhili MA, Alazmi SA, Alsughayyir JM.
europepmc   +1 more source

Investigation into the Pancreatic Pathogenesis of SFTSV across Multiple Levels

Advanced Science, EarlyView.
A retrospective analysis revealed that 17.6% of severe fever with thrombocytopenia syndrome (SFTS) patients met the diagnostic criteria for clinically confirmed pancreatitis. Using human pancreatic organoids and murine models demonstrated that SFTSV exhibits a specific pancreatic tropism, leading to cell death and initiating a strong inflammatory ...
Xiaohan Liu, Zhihao Xu, Yilun Tong, Changtai Wang, Yueqi Yao, Yujie Diao, Jingyuan Ma, Shijun Zhou, Yinan Du, Zhenhua Zhang, Gang Xu   +10 more
wiley   +1 more source

Micro/Nanorobots for Combating Brain Disorders: Challenges, Advances, and Perspectives

Advanced Science, EarlyView.
Micro/nanorobots (MNRs) offer a transformative approach for precision therapy in brain disorders. By overcoming biological barriers and enabling controlled propulsion, targeted delivery, and real‐time imaging/tracking, MNRs pave the way toward effective, minimally invasive treatments. This review outlines the interplay between brain disease challenges,
Qi Zhang, Dong Sun
wiley   +1 more source

Critical Illness-Associated Cerebral Microbleed in a Young Patient With Sickle Cell Disease. [PDF]

Cureus
Pius R, Shaaban MM, Suarez JA.
europepmc   +1 more source