Results 61 to 70 of about 1,558,786 (324)
Molecular Oncology, EarlyView.This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris +10 more
wiley +1 more source
STOP-IT: strategic, tactical, operational protection of water infrastructure against cyberphysical threats [PDF]
, 2018 Water supply and sanitation infrastructures are essential for our welfare, but vulnerable to several attack types facilitated by the ever-changing landscapes of the digital world.
Bonet Gil, Enrique +2 more
core +1 more source
Critical Infrastructure Safety Management [PDF]
Transactions on Transport Sciences, 2009 Critical infrastructure is a set of mutually interconnected networks, i.e., the systems of various sectors of a human system. An interconnection of systems means their mutual dependence. Therefore, in connection with safe critical infrastructure and with sustainable development potential, it is necessary to solve several problems, namely the safety of ...
openaire +1 more source
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics
FEBS Open Bio, EarlyView.Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini +2 more
wiley +1 more source
Trends in critical infrastructure protection in Germany [PDF]
, 2014 Critical Infrastructures failures cause harmful consequences to the population, because they disrupt the supply of necessary goods and services. The failures pose an indirect threat, as they will regularly be triggered by natural hazards, technical ...
Eismann, Christine
core +1 more source
FEBS Open Bio, EarlyView.Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid +3 more
wiley +1 more source
Aid and AIDS: a delicate cocktail [PDF]
, 2008 Development assistance targeting health overwhelmingly concentrates on HIV/AIDS. This column argues that that focus neglects critical demographic issues and degrades health infrastructure, particularly in Sub-Saharan Africa.
Dalen van, H.P., Reuser, M.
core +1 more source
Early warning system for the prevention and control of unauthorized accesses to air navigation services infrastructures [PDF]
, 2015 Early warning systems are fundamental instruments for the management of critical situations since they are able to signal in advance any anomaly with respect to ordinary situations.
Accettura, Antonella +5 more
core +1 more source
FEBS Open Bio, EarlyView.dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon +6 more
wiley +1 more source