Results 161 to 170 of about 129,036 (402)

Risk factors for critical limb ischemia in patients undergoing femoral cannulation for venoarterial extracorporeal membrane oxygenation: Is distal limb perfusion a mandatory approach?

open access: yesPerfusion, 2019
Background: Venoarterial extracorporeal membrane oxygenation support is a well-established tool in the care of severe refractory cardiac and respiratory failure.
T. Kaufeld   +11 more
semanticscholar   +1 more source

Cistanche tubulosa improves peripheral neuropathy in MPTP‐induced PD mice based on regulation of m6A methylation

open access: yesAnimal Models and Experimental Medicine, EarlyView.
At steady state, DRG ensures low‐level expression of TH+ neurons under the protection of AKT. However, the DRG level of PD mouse model under MPTP toxicity increased significantly, and the expression of IL‐6 and CASP3 increased. This process was accompanied by the occurrence of m6A demethylation, with a significant increase in FTO as the main ...
Yatan Li   +6 more
wiley   +1 more source

Research advances in dysphagia animal models

open access: yesAnimal Models and Experimental Medicine, EarlyView.
This review systematically summarizes the establishment, evaluation, and detection of dysphagia animal models in stroke, Parkinson's disease (PD), and amyotrophic lateral sclerosis (ALS) in three kinds of experimental animals (including rodents, nonhuman primates, and other mammals), providing a basis for the selection of appropriate animal models of ...
Junhui Bai   +5 more
wiley   +1 more source

Research progress on traditional Chinese medicine animal models of post‐stroke depression and pathological insights

open access: yesAnimal Models and Experimental Medicine, EarlyView.
Post‐stroke depression (PSD) animal model of traditional Chinese medicine (TCM) combined with disease and syndrome often uses western medicine surgery (including: middle cerebral artery embolization to construct cerebral ischemia, or brain injection of collagenase to construct cerebral hemorrhage) combined with other methods (including: isolation ...
Jielin Wang   +4 more
wiley   +1 more source

The FindMNDBiomarker Program: Protein Changes in Motor Neuron Disease/Amyotrophic Lateral Sclerosis Postmortem Tissue and Biofluids

open access: yesAnnals of Neurology, EarlyView.
Objective Biomarkers of disease pathogenesis are critically needed for amyotrophic lateral sclerosis (ALS) to facilitate diagnosis and patient stratification into appropriate therapeutic trials. Proteomic studies offer significant potential to advance this, but reproducibility across laboratories is a key component toward identifying protein changes ...
Gabrielle L. Adler   +2 more
wiley   +1 more source

Noninvasive Multimodal Imaging to Predict Recovery of Locomotion after Extended Limb Ischemia.

open access: yesPLoS ONE, 2015
Acute limb ischemia is a common cause of morbidity and mortality following trauma both in civilian centers and in combat related injuries. Rapid determination of tissue viability and surgical restoration of blood flow are desirable, but not always ...
Jason S Radowsky   +6 more
doaj   +1 more source

Gout and NLRP3 Inflammasome Biology

open access: yesArthritis &Rheumatology, EarlyView.
This review describes the three broad stages of acute inflammation in the context of gout: initiation, leucocyte mobilization, and self‐resolution. A typical case of a gout flare is presented. The role of the NLRP3 inflammasome in acute monosodium urate crystal–induced inflammation is reviewed in detail.
Raewyn Poulsen, Nicola Dalbeth
wiley   +1 more source

Impact of diclofenac risk minimization measures addressing cardiovascular risk on analgesic use in musculoskeletal disorders

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Aims In 2013, risk minimization measures (RMMs) were introduced in Europe to address the increased cardiovascular risk linked to diclofenac. This study aimed to assess the impact of those RMMs on analgesic use. Methods Primary care data from CPRD GOLD (UK) were used.
Tomas Lasys   +5 more
wiley   +1 more source

Antibacterial hydrogel: The sniper of chronic wounds

open access: yesBMEMat, EarlyView.
The treatment of chronic wounds has always been an important challenge in the medical field. We focus on hydrogels not only because they provide a moist healing environment but also because compared with traditional dressings, they can effectively prevent and treat infections, reduce wound pain and scar formation.
Shengtai Bian   +6 more
wiley   +1 more source

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