Results 11 to 20 of about 107,923 (299)

Revascularization and limb salvage following critical limb ischemia by nanoceria-induced Ref-1/APE1-dependent angiogenesis.

Biomaterials, 2020
In critical limb ischemia (CLI), overproduction of reactive oxygen species (ROS) and impairment of neovascularization contribute to muscle damage and limb loss.
I. Park, C. Mahapatra, J. S. Park, K. Dashnyam, Jong-Wan Kim, Jin-Chul Ahn, P. Chung, D. Yoon, Nandin Mandakhbayar, R. Singh, Jung-Hwan Lee, K. Leong, H. Kim   +12 more
semanticscholar   +3 more sources

Perfusion Assessment in Critical Limb Ischemia: Principles for Understanding and the Development of Evidence and Evaluation of Devices: A Scientific Statement From the American Heart Association.

Circulation, 2019
There are >12 million patients with peripheral artery disease in the United States. The most severe form of peripheral artery disease is critical limb ischemia (CLI). The diagnosis and management of CLI is often challenging.
S. Misra, M. Shishehbor, E. Takahashi, H. Aronow, L. Brewster, M. Bunte, E. Kim, J. Lindner, K. Rich   +8 more
semanticscholar   +3 more sources

Comparative analysis of mouse bone marrow and adipose tissue mesenchymal stem cells for critical limb ischemia cell therapy

Stem cell research & therapeutics, 2021
Introduction Critical limb ischemia (CLI) is the most advanced form of peripheral arterial disease (PAD) characterized by ischemic rest pain and non-healing ulcers.
Pegah Nammian, S. Asadi-Yousefabad, Sajad Daneshi, M. Sheikhha, S. Tabei, V. Razban   +5 more
semanticscholar   +1 more source

Free Flap Salvage in the Ischemic Foot: A Case Report

Archives of Plastic Surgery, 2022
We performed distal bypass and free flap transfer in a single-stage operation to repair an extensive soft tissue defect in an ischemic foot of an 84-year-old woman.
Dongkyung Seo, Yutaka Dannnoura, Riku Ishii, Keisuke Tada, Kunihiro Kawashima, Tetsunori Yoshida, Katsumi Horiuchi   +6 more
doaj   +1 more source

Bmal1 Downregulation Worsens Critical Limb Ischemia by Promoting Inflammation and Impairing Angiogenesis

Frontiers in Cardiovascular Medicine, 2021
Critical limb ischemia (CLI) is the most advanced clinical stage of peripheral vascular disease with high mobility and mortality. CLI patients suffer from lower extremity rest pain, ulceration, and gangrene caused by insufficient blood and oxygen supply.
Li-rong Xu, Yutong Liu, Qianyun Cheng, Yang Shen, Ye Yuan, Xiaolang Jiang, Xu Li, D. Guo, Jun‐hao Jiang, Chang-po Lin   +9 more
semanticscholar   +1 more source

Upper limb ischemia in a newborn following difficult delivery

Journal of Pediatric Surgery Case Reports, 2020
Neonatal limb ischemia is a very rare condition. The lower limb ischemia is more common than upper limb ischemia in incidence. The limb ischemia in such an age group urges for top urgent proper management.
Drkamal alzoghby, Drmedhat elsayed, DrOthman alamoudi, Drahmed Rezan   +3 more
doaj   +1 more source

Autologous cell therapy in diabetes‑associated critical limb ischemia: From basic studies to clinical outcomes (Review).

International Journal of Molecular Medicine, 2021
Cell therapy is becoming an attractive alternative for the treatment of patients with no‑option critical limb ischemia (CLI). The main benefits of cell therapy are the induction of therapeutic angiogenesis and neovascularization that lead to an increase ...
A. Magenta, M. C. Florio, M. Ruggeri, S. Furgiuele   +3 more
semanticscholar   +1 more source

Autologous Peripheral Blood Mononuclear Cells for Limb Salvage in Diabetic Foot Patients with No-Option Critical Limb Ischemia

Journal of Clinical Medicine, 2021
Peripheral blood mononuclear cells (PBMNCs) are reported to prevent major amputation and healing in no-option critical limb ischemia (NO-CLI). The aim of this study is to evaluate PBMNC treatment in comparison to standard treatment in NO-CLI patients ...
A. Scatena, P. Petruzzi, F. Maioli, F. Lucaroni, C. Ambrosone, G. Ventoruzzo, F. Liistro, D. Tacconi, Marianna Di Filippi, Nico Attempati, L. Palombi, L. Ercolini, L. Bolognese   +12 more
semanticscholar   +1 more source

Modern methods of stimulation of angiogenesis in patients with critical limb ischemia (review)

Journal of Education, Health and Sport, 2017
The term "critical ischemia of extremities" (critical limb ischemia) was first introduced by P.R.F. Bell in 1982 to refer to a group of diseases accompanied by pain in the legs at rest, trophic ulcers and distal necroses of the lower limbs.
I. A. Kryvoruchko, S. K.-T. Goni, M. S. Antonova, M. A. Sykal, U. M. Voronaja, M. A. Alexandrov, N. V. Lola   +6 more
doaj   +3 more sources

Crossing complex infrapopliteal lesions utilizing a front-end cutting technique: A report of two cases with a novel rotational atherectomy device

SAGE Open Medical Case Reports, 2023
Critical limb ischemia represents the most severe stage of peripheral vascular disease and patients often present with complex, calcified infrapopliteal lesions.
Siddhartha Rao, Anton Hnatov, Trisha Tarra, Amber Amparo, Mallika Bhargava   +4 more
doaj   +1 more source